{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into meibomian gland carcinoma (MGC) have identified that microRNA-3907 (miR-3907) is markedly up-regulated in carcinoma tissues compared to adjacent non-tumor tissues. Functional studies revealed that miR-3907 targets thrombospondin-1 (THBS1), a protein whose expression is significantly reduced in MGC tissues. Bioinformatic analyses and dual-luciferase reporter assays confirmed THBS1 as a direct target of miR-3907. In vitro experiments further demonstrated that over-expression of miR-3907 in MGC cells significantly enhances cellular proliferation and migration, while knock-down of this microRNA results in diminished proliferative and migratory capacities. Moreover, the suppression of THBS1 mimics the oncogenic effects of miR-3907, and simultaneous miR-3907 knock-down along with THBS1 inhibition partially rescues these effects, underscoring the regulatory role of miR-3907 in tumor cell behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C L Zhang, X Liu, M X Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Screening of differently expressed miRNAs and the mechanism of miR-3907 in meibomian gland carcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yan Ke Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112142-20210630-00313"}], "href": "https://doi.org/10.3760/cma.j.cn112142-20210630-00313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35280029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35280029"}]}]}]}