MIR3914-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 3914-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have advanced our understanding of regulatory molecules in diverse developmental processes. Investigations into the macro-ADP-ribosylhydrolase MacroD2, for example, have revealed its dynamic expression pattern in the developing brain—demonstrating robust expression in immature neurons and a shift to a synaptic localization as maturity is reached—which underlines its potential role in neural differentiation and central nervous system maturation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Complementary behavioural analyses in mouse knockout models of ADP‐ribosylhydrolases further highlight the importance of these enzymes in neuropsychiatric and motor functions, contributing to our overall understanding of the molecular regulators in neural systems."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a distinct yet complementary line of inquiry into post‐transcriptional regulation during tissue differentiation, bioinformatic analyses in amelogenesis imperfecta have identified several microRNAs as candidate regulators of enamel formation. Among these, MIR3914‑1 (reported as miR‑3914) was validated in human ameloblastoma (AM‑1) cells as a critical regulator of ameloblast differentiation through its modulation of genes essential for extracellular matrix formation. These findings underscore the potential role of MIR3914‑1 as a key post‐transcriptional mediator in dental tissue development and enamel matrix biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hidenori Ito, Rika Morishita, Makoto Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Neurosci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000492271"}], "href": "https://doi.org/10.1159/000492271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30227424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30227424"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kerryanne Crawford, Peter L Oliver, Thomas Agnew, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Behavioural Characterisation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Macrod1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Macrod2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Knockout Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10020368"}], "href": "https://doi.org/10.3390/cells10020368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33578760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33578760"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hiroki Yoshioka, Yin-Ying Wang, Akiko Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22042202"}], "href": "https://doi.org/10.3390/ijms22042202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33672174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33672174"}]}]}]}
NCBI Gene ID 100500836
API
Download Associations
Predicted Functions View MIR3914-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3914-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3914-1's ARCHS4 Predicted Functions.

Functional Associations

MIR3914-1 has 203 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3914-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3914-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3914-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3914-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3914-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3914-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3914-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3914-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3914-1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3914-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3914-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.