{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that miR-3917 plays a pivotal role in lung cancer progression by mediating communication between the tumor microenvironment and cancer cells. In particular, miR-3917 is found to be highly expressed in lung cancer tissues and is abundantly packaged within M2 macrophage‐derived exosomes. These exosomes act as delivery vehicles that transfer miR-3917 into lung cancer cells, where the microRNA subsequently regulates cell behavior by targeting G protein-coupled receptor kinase 6 (GRK6). Down-regulation of GRK6 through miR-3917 action leads to enhanced proliferation, migration, and invasion of lung cancer cells, thereby promoting tumor growth in vivo. This mechanism indicates that the M2 macrophage-derived exosomal transfer of miR-3917 contributes substantially to tumor progression, highlighting its potential as a therapeutic target in non-small cell lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sinuo Song, Yunping Zhao, Xiaoxing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2022-0162"}], "href": "https://doi.org/10.1515/hsz-2022-0162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36261031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36261031"}]}]}]}