MIR3921 Gene

HGNC Family Non-coding RNAs
Name microRNA 3921
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the zinc finger protein Wiz plays a multifaceted role in epigenetic regulation by serving as an important stabilizer and functional adaptor of the G9a/GLP histone methyltransferase complex. In embryonic stem cells, Wiz is required for the optimal formation and stabilization of the G9a/GLP heteromer, protecting G9a from degradation and linking it to CtBP-related co‐repressor machinery, thereby influencing H3K9 methylation at euchromatic regions and modulating transcriptional repression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work in neural tissues has further expanded the role of Wiz by demonstrating its dual function as both a transcriptional repressor and activator. In the brain, Wiz exhibits high expression levels where it occupies promoter regions and CTCF binding sites, orchestrating the expression of key neuronal genes such as the clustered protocadherins. Disruption of Wiz function leads to decreased expression of these genes and is accompanied by behavioral alterations, including an anxiety-like phenotype, thereby underscoring its critical contribution to proper neuronal development and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Ueda, Makoto Tachibana, Tsuyoshi Ikura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M603087200"}], "href": "https://doi.org/10.1074/jbc.M603087200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16702210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16702210"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Luke Isbel, Lexie Prokopuk, Haoyu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.15082"}], "href": "https://doi.org/10.7554/eLife.15082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27410475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27410475"}]}]}]}
NCBI Gene ID 100500859
API
Download Associations
Predicted Functions View MIR3921's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3921's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3921's ARCHS4 Predicted Functions.

Functional Associations

MIR3921 has 261 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR3921 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3921 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3921 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR3921 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3921 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3921 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3921 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3921 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3921 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3921 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3921 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3921 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3921 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.