{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a recent metabolic phenotype study, AHDC1 deficiency in a survivable mouse model was shown to cause early-onset adiposity and obesity. Both male and female mice exhibited reduced energy expenditure and respiratory quotient, with a later progression to hyperleptinemia, insulin resistance, deranged glycolipid metabolism, and fatty liver. This work highlights AHDC1 as a novel key regulator of obesity and whole‐body energy metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Tincidunt vel sagittis quam convallis varius phasellus tincidunt. Although the study provides extensive insight into the metabolic implications of AHDC1 deficiency, no experimental or bioinformatic evidence regarding the function of MIR3924 is discussed. The interaction of MIR3924 with metabolic pathways, if any, remains undetermined in this context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. Mattis sem magna metus luctus purus vivamus adipiscing ex. Thus, while this research expands our understanding of the genetic regulation of obesity through AHDC1, it does not shed any light on the role or function of MIR3924. Further studies will be necessary to elucidate whether MIR3924 may contribute to these metabolic processes or interact with AHDC1-mediated pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Linyi Li, Shipeng Shao, Yu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ahdc1 is a potent regulator of obesity and energy metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00048.2023"}], "href": "https://doi.org/10.1152/ajpendo.00048.2023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37819197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37819197"}]}]}]}