{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that MIR3935 is significantly down-regulated in placental tissues from patients with preeclampsia, a condition linked to the insufficient trophoblast epithelial-mesenchymal transition (EMT) required for proper migration and invasion. This alteration in expression suggests that under normal conditions, MIR3935 may play a role in promoting the invasive properties and proper differentiation of trophoblast cells, thereby contributing to healthy placental development. However, the precise molecular mechanisms by which MIR3935 influences these processes remain to be defined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel with these findings in preeclampsia, studies focusing on other non-coding RNA molecules, such as the long non-coding RNA LINC00992, have implicated these regulatory RNAs in critical cellular functions during tumor progression. Although LINC00992 has been linked to cancer progression in several contexts, including prostate cancer, its functional characterization is still in its early stages. The emerging insights into the diverse roles of non-coding RNAs underscore the potential significance of MIR3935 as part of a broader network of RNA-mediated regulatory pathways that may also impact disease states beyond preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these observations highlight the need for further investigation into MIR3935's biological functions. Understanding its contribution to trophoblast EMT and placental development, as well as its possible interplay with other non-coding RNAs in pathological conditions such as cancer, could open new avenues for therapeutic intervention. Future studies aimed at delineating the molecular mechanisms underlying MIR3935 activity are therefore essential to fully exploit its potential as a biomarker or therapeutic target in complex disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meiyuan Jin, Shouying Xu, Jiayong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-021-00817-x"}], "href": "https://doi.org/10.1186/s12958-021-00817-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34493304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34493304"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianheng Chen, Xiaodong Liu, Kunbin Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00992 contributes to the oncogenic phenotypes in prostate cancer via targeting miR-3935 and augmenting GOLM1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-07141-4"}], "href": "https://doi.org/10.1186/s12885-020-07141-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32781986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32781986"}]}]}]}