MIR3938 Gene

HGNC Family Non-coding RNAs
Name microRNA 3938
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations in glioma have revealed that circCDK14 is frequently overexpressed in tumor tissues and cell lines, and its elevated levels correlate with poorer patient prognosis. Mechanistic studies demonstrated that circCDK14 functions by binding to—and effectively sequestering—miR‑3938, a microRNA that normally would help control the expression of oncogenic targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "By sponging miR‑3938, circCDK14 indirectly upregulates the expression of the oncogene PDGFRA, thereby facilitating increased cell migration, invasion, and proliferation. Furthermore, this circCDK14/miR‑3938/PDGFRA axis confers resistance to erastin‐induced ferroptosis in glioma cells, highlighting a critical role for miR‑3938 in modulating pathways that suppress tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "These findings underscore the potential of targeting the circCDK14/miR‑3938/PDGFRA signaling cascade as a novel therapeutic strategy against glioma. The data suggest that restoring the normal function of miR‑3938 or disrupting its sequestration by circCDK14 could mitigate PDGFRA-driven malignancy and improve treatment outcomes in glioma patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Simin Chen, Zhaoyu Zhang, Baoxin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.66114"}], "href": "https://doi.org/10.7150/ijbs.66114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35002529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35002529"}]}]}]}
NCBI Gene ID 100500875
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Predicted Functions View MIR3938's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3938's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3938's ARCHS4 Predicted Functions.

Functional Associations

MIR3938 has 155 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR3938 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3938 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3938 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3938 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3938 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3938 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3938 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3938 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3938 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3938 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.