{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided offers an extensive overview of the multifaceted roles of T-type calcium channels—especially the CaV3.2 isoform—in regulating vascular tone, cardiac and neuronal excitability, nociceptive signaling, synaptic transmission, development, and other physiological processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther work in this set of abstracts addresses mechanisms by which CaV3.2 channels influence pain processing, epileptogenesis, synaptic transmission and intracellular signaling in diverse cell types and tissues. These include modulation through redox regulation, deubiquitination by USP5, interactions with TRP channels, regulation by auxiliary subunits, and activity‐dependent plasticity—all of which underscore the channels’ central roles in cellular excitability and signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations extend the impact of CaV3.2 channel modulation to learning and memory, osteocyte mechanosensation, embryonic development, sperm physiology, gastrointestinal motility, and renal hemodynamics. These studies reveal how changes in CaV3.2 expression and activity—whether through interactions with environmental factors (such as hydrogen sulfide, nitrous oxide, or cannabinoids) or through alterations in intracellular signaling cascades—influence a broad spectrum of biological functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMeanwhile, several studies have focused on the molecular and cellular regulation of CaV3.2 channels—exploring roles for deubiquitinases like USP5, interactions with actin-binding proteins such as Kelch-like 1, and the consequent effects on neuron excitability, pain hypersensitivity, and neurodegenerative conditions—further illustrating the channels’ clinical relevance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "34", "end_ref": "42"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, pharmacological modulation of CaV3.2 channels and their contributions to analgesia, anti-hyperalgesia, neuroprotection, and even chemotherapeutic cardiotoxicity have been examined, emphasizing their diverse roles in both normal physiology and disease states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "43", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLastly, complementary studies have addressed how CaV3.2 channels influence vascular biomechanics, neuronal progenitor behavior, and sensory neuron development—in turn modulating arterial tone and renal function—thereby highlighting the comprehensive impact of these channels across multiple organ systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "47", "end_ref": "50"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, despite the extensive insights into T-type calcium channel biology provided by these publications, none of the studies explicitly mention or investigate MIR3942. As such, while the research underscores the pivotal regulatory functions of CaV3.2 channels in diverse biological contexts, the potential role or impact of MIR3942 in modulating these channels or their associated signaling pathways remains uncharacterized based on the current literature"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "50"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chien-Chang Chen, Kathryn G Lamping, Daniel W Nuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1089268"}], "href": "https://doi.org/10.1126/science.1089268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14631046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14631046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yucai Chen, Jianjun Lu, Hong Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between genetic variation of CACNA1H and childhood absence epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.10607"}], "href": "https://doi.org/10.1002/ana.10607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12891677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12891677"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Agustin García-Caballero, Vinicius M Gadotti, Patrick Stemkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2014.07.036"}], "href": "https://doi.org/10.1016/j.neuron.2014.07.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25189210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25189210"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Choi, H S Na, J Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Attenuated pain responses in mice lacking Ca(V)3.2 T-type channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Brain Behav (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1601-183X.2006.00268.x"}], "href": "https://doi.org/10.1111/j.1601-183X.2006.00268.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16939637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16939637"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Albert J Becker, Julika Pitsch, Dmitry Sochivko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1421-08.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.1421-08.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19052226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19052226"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Megan O Jacus, Victor N Uebele, John J Renger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0068-12.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.0068-12.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22764245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22764245"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chien-Sung Chiang, Ching-Hui Huang, Hockling Chieng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ca(v)3.2 T-type Ca(2+) channel is required for pressure overload-induced cardiac hypertrophy in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.108.184051"}], "href": "https://doi.org/10.1161/CIRCRESAHA.108.184051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19122177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19122177"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Noriko Niwa, Kenji Yasui, Tobias Opthof, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.01043.2003"}], "href": "https://doi.org/10.1152/ajpheart.01043.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14988077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14988077"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Pavle M Joksovic, Michael T Nelson, Vesna Jevtovic-Todorovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2006.110395"}], "href": "https://doi.org/10.1113/jphysiol.2006.110395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16644797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16644797"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wen-Kwei Chen, Ingrid Y Liu, Ya-Ting Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1041-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.1041-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20685979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20685979"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xavier F Figueroa, Chien-Chang Chen, Kevin P Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.01368.2006"}], "href": "https://doi.org/10.1152/ajpheart.01368.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17513486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17513486"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jun Wan, Aya Yamamura, Adriana M Zimnicka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00313.2012"}], "href": "https://doi.org/10.1152/ajplung.00313.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23686856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23686856"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "K E Rose, N Lunardi, A Boscolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2013.07.005"}], "href": "https://doi.org/10.1016/j.neuroscience.2013.07.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23867767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23867767"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Vinicius M Gadotti, Agustin Garcia Caballero, N Daniel Berger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12990-015-0011-8"}], "href": "https://doi.org/10.1186/s12990-015-0011-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25889575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25889575"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kazumasa Okubo, Midori Matsumura, Yudai Kawaishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1476-5381.2012.01886.x"}], "href": "https://doi.org/10.1111/j.1476-5381.2012.01886.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22300342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22300342"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "William R Thompson, Amber S Majid, Kirk J Czymmek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the α(2)δ(1) subunit with Ca(v)3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.437"}], "href": "https://doi.org/10.1002/jbmr.437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21638318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21638318"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ying Shao, Michael Alicknavitch, Mary C Farach-Carson "}, {"type": "b", "children": [{"type": "t", "text": "Expression of voltage sensitive calcium channel (VSCC) L-type Cav1.2 (alpha1C) and T-type Cav3.2 (alpha1H) subunits during mouse bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20517"}], "href": "https://doi.org/10.1002/dvdy.20517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16059921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16059921"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maho Matsunami, Takahiro Miki, Kanae Nishiura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the endogenous hydrogen sulfide/Ca(v) 3.2 T-type Ca2+ channel pathway in cystitis-related bladder pain in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1476-5381.2012.02060.x"}], "href": "https://doi.org/10.1111/j.1476-5381.2012.02060.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22646666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22646666"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Karen M J van Loo, Christina Schaub, Katharina Pernhorst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.310763"}], "href": "https://doi.org/10.1074/jbc.M111.310763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22431737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22431737"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yogananda S Markandeya, Laura J Phelan, Marites T Woon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.674945"}], "href": "https://doi.org/10.1074/jbc.M115.674945"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26170457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26170457"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Shin-Shiou Lin, Bing-Hsiean Tzeng, Kuan-Rong Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1323112111"}], "href": "https://doi.org/10.1073/pnas.1323112111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24778262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24778262"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nicolas Kerckhove, Christophe Mallet, Amaury François, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ca(v)3.2 calcium channels: the key protagonist in the supraspinal effect of paracetamol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pain (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pain.2014.01.015"}], "href": "https://doi.org/10.1016/j.pain.2014.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24447516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24447516"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Woo Yong Lee, Peihan Orestes, Janelle Latham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5803-08.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.5803-08.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19641113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19641113"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Rui Wang, Gary R Lewin "}, {"type": "b", "children": [{"type": "t", "text": "The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2010.203463"}], "href": "https://doi.org/10.1113/jphysiol.2010.203463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21486775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21486775"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Chien-Chang Chen, Jhe-Wei Shen, Ni-Chun Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retrieval of context-associated memory is dependent on the Ca(v)3.2 T-type calcium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029384"}], "href": "https://doi.org/10.1371/journal.pone.0029384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22235292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22235292"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Pamela Cabahug-Zuckerman, Randy F Stout, Robert J Majeska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role for a specialized β"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "3"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " integrin-based structure on osteocyte processes in bone mechanosensation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.23792"}], "href": "https://doi.org/10.1002/jor.23792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29087614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29087614"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Sonja L Joksimovic, Srdjan M Joksimovic, Vesna Tesic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective inhibition of Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "V"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aao4425"}], "href": "https://doi.org/10.1126/scisignal.aao4425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30154101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30154101"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yogananda S Markandeya, Jonathan M Fahey, Florentina Pluteanu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.182550"}], "href": "https://doi.org/10.1074/jbc.M110.182550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21084288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21084288"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Miranda L Bernhardt, Paula Stein, Ingrid Carvacho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPM7 and Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "V"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "3.2 channels mediate Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " influx required for egg activation at fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1810422115"}], "href": "https://doi.org/10.1073/pnas.1810422115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30322909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30322909"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Maho Tsubota-Matsunami, Yumi Noguchi, Yasumasa Okawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colonic hydrogen sulfide-induced visceral pain and referred hyperalgesia involve activation of both Ca(v)3.2 and TRPA1 channels in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1254/jphs.12086sc"}], "href": "https://doi.org/10.1254/jphs.12086sc"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22785020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22785020"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Karen M J van Loo, Christina Schaub, Julika Pitsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9688"}], "href": "https://doi.org/10.1038/ncomms9688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26498180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26498180"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Osama F Harraz, Suzanne E Brett, Anil Zechariah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.115.305736"}], "href": "https://doi.org/10.1161/ATVBAHA.115.305736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26069238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26069238"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Miriam Candelas, Ana Reynders, Margarita Arango-Lievano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-39703-3"}], "href": "https://doi.org/10.1038/s41598-019-39703-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30816223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30816223"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Patrick L Stemkowski, Agustin Garcia-Caballero, Vinicius M Gadotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1744806917724698"}], "href": "https://doi.org/10.1177/1744806917724698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28741432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28741432"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Patrick Stemkowski, Agustin García-Caballero, Vinicius De Maria Gadotti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.11.047"}], "href": "https://doi.org/10.1016/j.celrep.2016.11.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27974205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27974205"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "José A Rodríguez-Gómez, Konstantín L Levitsky, José López-Barneo "}, {"type": "b", "children": [{"type": "t", "text": "T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00267.2011"}], "href": "https://doi.org/10.1152/ajpcell.00267.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22049210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22049210"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Miranda L Bernhardt, Yingpei Zhang, Christian F Erxleben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CaV3.2 T-type channels mediate Ca²⁺ entry during oocyte maturation and following fertilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.180026"}], "href": "https://doi.org/10.1242/jcs.180026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26483387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26483387"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Jessica Escoffier, Sylvie Boisseau, Catherine Serres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.21075"}], "href": "https://doi.org/10.1002/jcp.21075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17450521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17450521"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "John D Graef, Brian K Nordskog, Walter F Wiggins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0198-09.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.0198-09.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19357270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19357270"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Simon J Gibbons, Peter R Strege, Sha Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2008.00623.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2008.00623.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19413888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19413888"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "K A Aromolaran, K A Benzow, L L Cribbs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T-type current modulation by the actin-binding protein Kelch-like 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00235.2009"}], "href": "https://doi.org/10.1152/ajpcell.00235.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20147652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20147652"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Yi-Fang Liao, Meng-Li Tsai, Chien-Chang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the Cav3.2 T-type calcium channel in thalamic neuron discharge patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-8069-7-43"}], "href": "https://doi.org/10.1186/1744-8069-7-43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21639922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21639922"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Peihan Orestes, Damir Bojadzic, Jeonghan Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2010.196220"}], "href": "https://doi.org/10.1113/jphysiol.2010.196220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21059758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21059758"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Yuriy Rzhepetskyy, Joanna Lazniewska, Iulia Blesneac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CACNA1H missense mutations associated with amyotrophic lateral sclerosis alter Cav3.2 T-type calcium channel activity and reticular thalamic neuron firing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Channels (Austin) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19336950.2016.1204497"}], "href": "https://doi.org/10.1080/19336950.2016.1204497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27331657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27331657"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "N Daniel Berger, Vinicius M Gadotti, Ravil R Petrov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-8069-10-77"}], "href": "https://doi.org/10.1186/1744-8069-10-77"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25481027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25481027"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Junxia Hu, Qi Wu, Zhiwei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2019.109475"}], "href": "https://doi.org/10.1016/j.biopha.2019.109475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31580970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31580970"}]}, {"type": "r", "ref": 47, "children": [{"type": "t", "text": "Miriam F Mikkelsen, Karl Björling, Lars Jørn Jensen "}, {"type": "b", "children": [{"type": "t", "text": "Age-dependent impact of Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "V"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " 3.2 T-type calcium channel deletion on myogenic tone and flow-mediated vasodilatation in small arteries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/JP271470"}], "href": "https://doi.org/10.1113/JP271470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26752249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26752249"}]}, {"type": "r", "ref": 48, "children": [{"type": "t", "text": "Lauri M Louhivuori, Verna Louhivuori, Henna-Kaisa Wigren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of low voltage activated calcium channels in neuritogenesis and active migration of embryonic neural progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2012.0234"}], "href": "https://doi.org/10.1089/scd.2012.0234"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23234460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23234460"}]}, {"type": "r", "ref": 49, "children": [{"type": "t", "text": "Laurence Autret, Ilana Mechaly, Frédérique Scamps, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The involvement of Cav3.2/alpha1H T-type calcium channels in excitability of mouse embryonic primary vestibular neurones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2005.089342"}], "href": "https://doi.org/10.1113/jphysiol.2005.089342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15961427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15961427"}]}, {"type": "r", "ref": 50, "children": [{"type": "t", "text": "Anne D Thuesen, Henrik Andersen, Majken Cardel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00016.2014"}], "href": "https://doi.org/10.1152/ajprenal.00016.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24966091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24966091"}]}]}]}