MIR3960 Gene

HGNC Family Non-coding RNAs
Name microRNA 3960
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have uncovered a dual role for miR‑3960 in cancer biology. In colorectal cancer, miR‑3960 functions as a key regulatory node within the LINC01605/miR‑3960/SOX11 axis, where it modulates the expression of SOX11. This regulation appears to influence the biological behavior of colorectal cancer cells, potentially affecting processes such as cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, in the context of triple‑negative breast cancer (TNBC), miR‑3960 has been identified as a critical mediator of cisplatin resistance. Tumor microenvironment (TME)‐derived exosomes laden with miR‑3960 are secreted by SOD1‑upregulated fibroblasts and subsequently internalized by TNBC cells. Within these cells, miR‑3960 directly targets and suppresses BRSK2, a kinase that is involved in the ubiquitin‑mediated degradation of PIMREG. The resulting accumulation and S16 phosphorylation of PIMREG effectively activate the NF‑κB signaling pathway, thereby promoting chemoresistance to cisplatin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S-S Hu, L Fu, S-Y Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01605 regulates proliferation, migration and invasion of colorectal cancer cells via targeting miR-3960/SOX11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_24837"}], "href": "https://doi.org/10.26355/eurrev_202102_24837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629302"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kangdi Li, Han Lin, Anyi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOD1-high fibroblasts derived exosomal miR-3960 promotes cisplatin resistance in triple-negative breast cancer by suppressing BRSK2-mediated phosphorylation of PIMREG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.216842"}], "href": "https://doi.org/10.1016/j.canlet.2024.216842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38582395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38582395"}]}]}]}
NCBI Gene ID 100616250
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Predicted Functions View MIR3960's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3960's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3960's ARCHS4 Predicted Functions.

Functional Associations

MIR3960 has 1,460 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3960 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3960 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3960 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3960 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3960 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3960 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3960 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3960 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3960 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR3960 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3960 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.