{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have uncovered a role for miR-3976 in modulating the host innate immune response during Cryptosporidium parvum infection. In intestinal HCT-8 cells, miR-3976 appears to regulate apoptosis, a key process in the cellular response to the pathogen, thereby influencing the severity of cryptosporidiosis—a condition recognized as a major cause of diarrhea in young children. This finding sheds light on the molecular interplay between host defense mechanisms and parasitic infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate context, miR-3976 has also been implicated in the pathogenesis of hepatocellular carcinoma (HCC) through its post-transcriptional regulation of CD147 expression. Here, a single nucleotide polymorphism (rs6757) was found to affect the binding efficacy of miR-3976 to the 3′-untranslated region (3′-UTR) of CD147. This altered binding modulates gene expression, with consequences for tumor proliferation, invasion, and overall prognosis, suggesting that miR-3976 may serve as a pivotal factor in modulating cancer risk in affected populations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Juanfeng Li, Lulu Sun, Fujie Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3976 regulates HCT-8 cell apoptosis and parasite burden by targeting BCL2A1 in response to Cryptosporidium parvum infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parasit Vectors (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13071-023-05826-w"}], "href": "https://doi.org/10.1186/s13071-023-05826-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37415254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37415254"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fenfen Guo, Hong Li, Lizhong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rs6757 in microRNA-3976 binding site of CD147 confers risk of hepatocellular carcinoma in South Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12957-022-02724-w"}], "href": "https://doi.org/10.1186/s12957-022-02724-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35978360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35978360"}]}]}]}