{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐4262 has been implicated in multiple malignancies with seemingly divergent roles. In osteosarcoma, reduced expression of miR‐4262 is associated with increased osteopontin levels, enhanced cancer cell invasion, and poorer patient survival, suggesting that miR‐4262 normally functions to restrain OPN‐mediated invasion by directly targeting OPN mRNA (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, miR‐4262 is overexpressed and promotes cell cycle progression and proliferation via direct inhibition of the tumor suppressor PDCD4 and activation of NF‐κB signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Likewise, in breast cancer, elevated miR‐4262 levels enhance cellular proliferation and invasion by targeting the tumor suppressors KLF6 and KLF15."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in colon and cervical cancers, miR‐4262 acts as a tumor suppressor. In colon cancer cell models, overexpression of miR‐4262 decreases the expression of GALNT4, leading to suppressed cell viability, growth, and cell‐cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in cervical cancer, miR‐4262 is downregulated and its enforced expression inhibits proliferation and epithelial–mesenchymal transition (EMT) by directly downregulating the transcription factor Kaiso."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, although miR‐4262 levels are lower compared to adjacent tissues, restoration of miR‐4262 negatively regulates GRP78, contributing to reduced cellular proliferation and enhanced apoptosis, which was also reflected in xenograft models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies reveal a context‐dependent oncogenic potential of miR‐4262. In cutaneous malignant melanoma, miR‐4262 is upregulated where it targets KLF6 and, through subsequent modulation of EGFR activation and p21 expression, drives melanoma cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In an acute lung injury model, the long non‐coding RNA MEG3 acts as a sponge for miR‐4262, and MEG3 knockdown aggravates LPS-induced lung cell injury by permitting miR‐4262–mediated downregulation of KLF4, implicating miR‐4262 in lung cell apoptosis and impaired cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, preliminary data in glioma suggest that miR‐4262 may promote proliferation and migration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while ongoing investigations in esophageal cancer aim to establish its expression patterns and prognostic significance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kun Song, Ning Liu, Yan Yang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14732514133203"}], "href": "https://doi.org/10.3727/096504016X14732514133203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27629257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27629257"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jian-Jun Qu, Xiang-Yang Qu, De-Zhen Zhou "}, {"type": "b", "children": [{"type": "t", "text": "miR‑4262 inhibits colon cancer cell proliferation via targeting of GALNT4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7057"}], "href": "https://doi.org/10.3892/mmr.2017.7057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28731150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28731150"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Feng "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504017X15021536183526"}], "href": "https://doi.org/10.3727/096504017X15021536183526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28800784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28800784"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shaosheng Liu, Yuanyuan Li, Zhaoxia Li "}, {"type": "b", "children": [{"type": "t", "text": "Salidroside suppresses the activation of nasopharyngeal carcinoma cells via targeting miR-4262/GRP78 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.2019976"}], "href": "https://doi.org/10.1080/15384101.2021.2019976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35220889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35220889"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dingwei Zhang, Zhangjun Li, Yanfei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4262 promotes the proliferation of human cutaneous malignant melanoma cells through KLF6-mediated EGFR inactivation and p21 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5190"}], "href": "https://doi.org/10.3892/or.2016.5190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27779691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27779691"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaoliang Li, Qianqian Zhang, Zhigang Yang "}, {"type": "b", "children": [{"type": "t", "text": "Silence of MEG3 intensifies lipopolysaccharide-stimulated damage of human lung cells through modulating miR-4262."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1623233"}], "href": "https://doi.org/10.1080/21691401.2019.1623233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31184231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31184231"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chunbo Liu, Tao Ma, Tianwei Jiang, et al. 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