MIR4267 Gene

HGNC Family Non-coding RNAs
Name microRNA 4267
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have extensively characterized genomic regions that harbor high degrees of structural complexity, notably at the salivary α‐amylase locus where multi‐allelic copy number variation is prevalent. One study (PMID 26098870:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "detailed the structural haplotypes of the amylase locus and provided precise quantitative measures of AMY1 copy number, which, despite previous reports associating these variations with obesity, did not confirm any direct phenotypic influence on body mass index."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nDissecting a complementary aspect of this genomic region, another study (PMID 26132294:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "investigated the interplay between AMY1 copy number, serum amylase levels, and childhood-onset obesity. Although the work was meticulously designed and well-powered to detect associations with obesity metrics, the analysis did not explore or report any functional involvement of MIR4267 in modulating these metabolic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nIn summary, while both studies significantly enhanced our understanding of genomic variability at the amylase locus and its potential contributions to obesity, neither provided insights into a functional role for MIR4267. As such, the current body of work remains silent on MIR4267’s biological function or its prospective regulatory impact within these genomic contexts, leaving its characterization as an open question for future research."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christina L Usher, Robert E Handsaker, Tõnu Esko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3340"}], "href": "https://doi.org/10.1038/ng.3340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26098870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26098870"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Heli Viljakainen, Johanna C Andersson-Assarsson, Miriam Armenio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0131883"}], "href": "https://doi.org/10.1371/journal.pone.0131883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26132294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26132294"}]}]}]}
NCBI Gene ID 100422994
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Predicted Functions View MIR4267's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4267's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4267's ARCHS4 Predicted Functions.

Functional Associations

MIR4267 has 164 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 4 datasets.

Click the + buttons to view associations for MIR4267 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4267 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4267 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4267 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4267 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.