{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR-4268 as a tumor suppressor in gastric cancer, exerting its function by directly targeting and negatively regulating the expression of keratin 80 (KRT80). In gastric cancer tissues and cell lines, miR-4268 is found to be significantly downregulated in contrast to the heightened levels of KRT80 observed in these samples. Functional assays demonstrated that the suppression of KRT80 leads to decreased cell viability, proliferation, and migration, along with an increase in apoptosis. Moreover, mechanistic investigations revealed that miR-4268 exerts its tumor‐suppressive effects by inhibiting key oncogenic signaling pathways, notably the PI3K/AKT/JNK cascades, via its interaction with KRT80. Collectively, these findings highlight the critical role of the miR-4268/KRT80 axis in the pathogenesis of gastric cancer and suggest that therapeutic strategies aimed at restoring miR-4268 levels could effectively disrupt tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan Zhang, Guoxian Wang, Wenjuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4268 suppresses gastric cancer genesis through inhibiting keratin 80."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2022.2085351"}], "href": "https://doi.org/10.1080/15384101.2022.2085351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35748914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35748914"}]}]}]}