MIR4269 Gene

HGNC Family Non-coding RNAs
Name microRNA 4269
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the tumor‐suppressive role of miR‑4269 in different cancer types. In gastric cancer, miR‑4269 was shown to directly target and inhibit the expression of TEAD1 and TEAD4—key transcriptional regulators in the Hippo‑YAP1 pathway—thereby suppressing oncogenic signaling. Reduced miR‑4269 levels in primary gastric tumors correlated with elevated TEAD4 expression and poorer disease‐specific survival, underscoring its potential as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic cancer, miR‑4269 expression was found to be lower than in normal tissues. Functional assays revealed that restoration of miR‑4269 significantly inhibited pancreatic cancer cell proliferation, migration, and invasion. Mechanistically, miR‑4269 directly targets ZEB1, a transcription factor that in turn activates the expression of the oncogene OTX1. By attenuating the ZEB1/OTX1 axis, miR‑4269 exerts its tumor‑suppressive effects and presents a promising therapeutic target for this aggressive malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y Zhou, T Huang, J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.257"}], "href": "https://doi.org/10.1038/onc.2017.257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28759040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28759040"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xin Sui, Zhenghui Sui "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4269 suppresses the tumorigenesis and development of pancreatic cancer by targeting ZEB1/OTX1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20200010"}], "href": "https://doi.org/10.1042/BSR20200010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32484209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32484209"}]}]}]}
NCBI Gene ID 100423043
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Predicted Functions View MIR4269's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4269's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4269's ARCHS4 Predicted Functions.

Functional Associations

MIR4269 has 319 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4269 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4269 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4269 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4269 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4269 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4269 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR4269 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4269 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4269 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4269 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.