{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch into microRNA‐4270 (miR-4270) has revealed its multifaceted role in cancer biology, particularly in hepatocellular carcinoma (HCC). In HCC cells, overexpression of miR-4270-5p has been shown to suppress cell proliferation and invasion by directly targeting the transcriptional regulator SATB2, thereby reversing epithelial–mesenchymal transition and curbing tumor aggressiveness. These findings suggest that miR-4270 can function as a tumor suppressor and may offer prognostic and therapeutic potential in HCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in HCC, miR-4270 has been implicated in modulating the response to irradiation and metastatic behavior in other cancer models. In nasopharyngeal carcinoma, lower expression levels of miR-4270 (among the top differential microRNAs distinguishing radio-sensitive from radio-resistant patients) result in altered p53 regulation, where inhibition of miR-4270 increases cell sensitivity to irradiation. Furthermore, studies employing miR-4270 inhibitors in HepG2 cells have demonstrated decreased cell migration and matrix metalloproteinase activity, highlighting its potential involvement in metastasis suppression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond oncological contexts, miR-4270 also appears to play a role in inflammatory conditions. In rheumatoid arthritis, circulating levels of miR-4270 are significantly upregulated compared with healthy individuals, and its expression correlates with key metabolic and inflammatory markers. This association not only emphasizes the microRNA’s potential as a non-invasive biomarker for rheumatoid arthritis but also suggests that miR-4270 might serve as a molecular link between inflammation and metabolic disturbances."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yun Wang, Chang-Feng Li, Li-Bo Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-4270-5p inhibits cancer cell proliferation and metastasis in hepatocellular carcinoma by targeting SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00384-0"}], "href": "https://doi.org/10.1007/s13577-020-00384-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32504285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32504285"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qiang Zou, Shasha Cao "}, {"type": "b", "children": [{"type": "t", "text": "miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.16566"}], "href": "https://doi.org/10.7717/peerj.16566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38077422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38077422"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wenwei Hao, Yongping Zhu, Haowei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4270 Modulates the Irradiation-Sensitivity of Nasopharyngeal Carcinoma Cells through Modulation of p53 in Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tohoku J Exp Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1620/tjem.254.63"}], "href": "https://doi.org/10.1620/tjem.254.63"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34078755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34078755"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hassan Akrami, Hanieh Gholami, Mohammad Reza Fattahi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of miR-4270 Suppression on Migration in Hepatocellular Carcinoma Cell Line (HepG2)"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Iran Biomed J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.61186/ibj.3923"}], "href": "https://doi.org/10.61186/ibj.3923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37430248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37430248"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sepideh Ghodoosifar, Gholamreza Dehghan, Reza Safaralizadeh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Iran J Allergy Asthma Immunol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18502/ijaai.v22i6.14643"}], "href": "https://doi.org/10.18502/ijaai.v22i6.14643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38477951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38477951"}]}]}]}