MIR4275 Gene

HGNC Family Non-coding RNAs
Name microRNA 4275
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts explicitly mention MIR4275, the collective results describe the functions of ILDR1—an angulin family protein whose roles in epithelial physiology might underlie what some annotations refer to as MIR4275. In the inner ear, ILDR1 is critical for maintaining the functional integrity of tricellular tight junctions (tTJs) by recruiting tricellulin to these specialized cell–cell contacts. Disruption of ILDR1 leads to mislocalization of tricellulin and early postnatal degeneration of cochlear hair cells, ultimately resulting in profound sensorineural deafness. While related proteins such as LSR and ILDR2 can be detected in epithelia, only ILDR1 is essential for establishing the strong barrier properties required for auditory function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the gastrointestinal tract, ILDR1 is exclusively expressed in cholecystokinin (CCK)-secreting enteroendocrine cells, where it plays a pivotal role in nutrient sensing. Activation of ILDR1 by a coordinated input of dietary fatty acids and high‐density lipoproteins leads to a rise in intracellular calcium that triggers CCK secretion. This hormone release is a key component of the satiety response, and genetic deletion of ILDR1 impairs fat‐mediated CCK secretion as well as alters metabolic activity and food intake regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nILDR1 further contributes to epithelial barrier function in the kidney. It is localized at tricellular tight junctions in the renal distal tubules and modulates paracellular water permeability without affecting ionic flux. Loss of ILDR1 in the kidney results in increased water leak, causing a renal concentrating defect manifested clinically as polyuria and polydipsia. This finding underscores the broader role of ILDR1 in regulating paracellular permeability across diverse tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tomohito Higashi, Shinsaku Tokuda, Shin-ichiro Kitajiri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.116442"}], "href": "https://doi.org/10.1242/jcs.116442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23239027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23239027"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eva L Morozko, Ayako Nishio, Neil J Ingham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu474"}], "href": "https://doi.org/10.1093/hmg/ddu474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25217574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25217574"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomohito Higashi, Tatsuya Katsuno, Shin-Ichiro Kitajiri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of angulin-2/ILDR1, a tricellular tight junction-associated membrane protein, causes deafness with cochlear hair cell degeneration in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0120674"}], "href": "https://doi.org/10.1371/journal.pone.0120674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25822906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25822906"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rashmi Chandra, Yu Wang, Rafiq A Shahid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI68587"}], "href": "https://doi.org/10.1172/JCI68587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23863714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23863714"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rashmi Chandra, Dipendra K Aryal, Jonathan D Douros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0270329"}], "href": "https://doi.org/10.1371/journal.pone.0270329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35749484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35749484"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yongfeng Gong, Nina Himmerkus, Abby Sunq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ILDR1 is important for paracellular water transport and urine concentration mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1701006114"}], "href": "https://doi.org/10.1073/pnas.1701006114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28461473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28461473"}]}]}]}
NCBI Gene ID 100422937
API
Download Associations
Predicted Functions View MIR4275's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4275's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4275's ARCHS4 Predicted Functions.

Functional Associations

MIR4275 has 183 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4275 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4275 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4275 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4275 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4275 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4275 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4275 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4275 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4275 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4275 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.