MIR4282 Gene

HGNC Family Non-coding RNAs
Name microRNA 4282
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐4282 (miR-4282) has emerged as a regulator of tumorigenesis in several cancer types. Initial investigations sought to explore its expression and potential oncogenic roles, with one study examining its expression in breast cancer cells and another evaluating its involvement in colorectal carcinoma via its potential correlation with semaphorin 3E. These early efforts raised the possibility that miR-4282 may be deregulated in cancers and warrant further functional evaluation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn subsequent, more mechanistically detailed studies, miR-4282 was found to function as a tumor suppressor in the context of oral squamous cell carcinoma by inhibiting proliferation, migration, and epithelial‐to‐mesenchymal transition while inducing apoptosis. Mechanistic analyses identified LIN28B as a direct target, with downstream effects on ZBTB2 mRNA stability, collectively contributing to the inhibition of tumor progression. A parallel study in epithelial ovarian cancer further implicated miR-4282 in the regulation of metastasis through modulation of MIER1. Together, these investigations highlight the multifaceted role of miR-4282 in cancer biology, suggesting its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xing Kang, Meng Wang, Hao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4282 suppresses proliferation and mobility of human colorectal carcinoma cells by targeting semaphorin 3E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Panminerva Med (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27120047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27120047"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Zhao, G-Q Jiang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4282 inhibits proliferation, invasion and metastasis of human breast cancer by targeting Myc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16643"}], "href": "https://doi.org/10.26355/eurrev_201812_16643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30575917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30575917"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Zhang, Zebiao Zhang, Wanling Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29458"}], "href": "https://doi.org/10.1002/jcp.29458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31970774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31970774"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Y Zuo, C-Y Liu, Q Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4282 is a tumor-suppressor gene for preventing metastasis of epithelial ovarian cancer by negatively regulating MIER1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202111_27232"}], "href": "https://doi.org/10.26355/eurrev_202111_27232"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34859847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34859847"}]}]}]}
NCBI Gene ID 100423005
API
Download Associations
Predicted Functions View MIR4282's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4282's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4282's ARCHS4 Predicted Functions.

Functional Associations

MIR4282 has 270 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR4282 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4282 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4282 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4282 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4282 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4282 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4282 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4282 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR4282 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4282 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4282 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.