MIR4283-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 4283-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In murine and Xenopus models, Fzd10 is required for late stages of sensory neuron differentiation and is dynamically expressed in the developing central nervous system. Moreover, FZD10 participates in non‐canonical as well as G protein–mediated signaling processes that influence CNS angiogenesis and potentially tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a complementary study exploring the role of microRNAs in modulating Wnt signaling, miR-26b-3p was found to target FZD10 in enteric glial cells (EGCs), leading to alterations in GSK3β/β-catenin signaling, increased apoptosis, and subsequent intestinal dysmotility. Although MIR4283-1 is not explicitly mentioned in these abstracts, its inclusion alongside these studies suggests it may function in a similar regulatory capacity—by targeting FZD10 or associated components of the Wnt pathway—to modulate developmental signaling, cell proliferation, differentiation, or apoptosis in specific tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhishan Wang, Weiguo Shu, Min Min Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.12.5022-5030.2005"}], "href": "https://doi.org/10.1128/MCB.25.12.5022-5030.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15923619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15923619"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Caroline R Kemp, Erik Willems, Danuta Wawrzak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21198"}], "href": "https://doi.org/10.1002/dvdy.21198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17576136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17576136"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Yan, Yiping Li, Chuanyin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Frizzled10 in mouse central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2008.11.001"}], "href": "https://doi.org/10.1016/j.gep.2008.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19056517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19056517"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaochun Gu, Yan Yan, Hanlin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genesis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvg.20472"}], "href": "https://doi.org/10.1002/dvg.20472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19241378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19241378"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carla Garcia-Morales, Chiung-Hui Liu, Muhammad Abu-Elmagd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frizzled-10 promotes sensory neuron development in Xenopus embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2009.08.021"}], "href": "https://doi.org/10.1016/j.ydbio.2009.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19716814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19716814"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Belma Hot, Jana Valnohova, Elisa Arthofer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FZD"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "10"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "-Gα"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "13"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " signalling axis points to a role of FZD"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "10"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " in CNS angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2017.01.023"}], "href": "https://doi.org/10.1016/j.cellsig.2017.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28126591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28126591"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Zhan, Yong Wen, Fan Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-023-03600-8"}], "href": "https://doi.org/10.1007/s12035-023-03600-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37728849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37728849"}]}]}]}
NCBI Gene ID 100422917
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Predicted Functions View MIR4283-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4283-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4283-1's ARCHS4 Predicted Functions.

Functional Associations

MIR4283-1 has 126 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.

Click the + buttons to view associations for MIR4283-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4283-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4283-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4283-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4283-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4283-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4283-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.