MIR4284 Gene

HGNC Family Non-coding RNAs
Name microRNA 4284
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-4284 has been identified as an oncogenic microRNA in gastric cancer where its expression is significantly upregulated in tumor tissues and cell lines. This upregulation correlates with advanced TNM stage, distal metastasis, and poor patient prognosis, as miR-4284 promotes cell proliferation, clone formation, invasion, and migration by directly targeting the tumor‐suppressive gene TET1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of inflammatory bone remodeling in ankylosing spondylitis, miR-4284 plays a key regulatory role in mesenchymal stem cells. Bioinformatics and functional studies have shown that miR-4284 controls the expression of the chemokine CXCL5: reduced miR-4284 levels lead to an increase in CXCL5 secretion, which in turn markedly inhibits osteoclastogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, the long non-coding RNA PGM5-AS1 has been found to suppress tumor cell malignancy through a molecular sponge mechanism that targets miR-4284. By sequestering miR-4284, PGM5-AS1 upregulates decorin (DCN) expression, thereby reducing cellular proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in ovarian carcinoma, elevated miR-4284 levels have been associated with paclitaxel resistance. Studies in paclitaxel-resistant ovarian cancer cell lines reveal that miR-4284 is upregulated and promotes malignant phenotypes by targeting DNA meiotic recombinase 1 (DMC1), thereby impairing chemosensitivity and contributing to cell proliferation and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yansen Li, Zhanlong Shen, Hongpeng Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑4284 promotes gastric cancer tumorigenicity by targeting ten-eleven translocation 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8671"}], "href": "https://doi.org/10.3892/mmr.2018.8671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29512746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29512746"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenjie Liu, Peng Wang, Zhongyu Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1448-x"}], "href": "https://doi.org/10.1038/s41419-019-1448-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30804325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30804325"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huimin Wang, Dan Wang, Qiong Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2062088"}], "href": "https://doi.org/10.1080/21655979.2022.2062088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35420507"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35420507"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hyun-Taek Kim, Paolo Panza, Khrievono Kikhi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT/RYK signaling functions as an antiinflammatory modulator in the lung mesenchyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2201707119"}], "href": "https://doi.org/10.1073/pnas.2201707119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35671428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35671428"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dongyan Sun, Di Shang, Pan Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000001314"}], "href": "https://doi.org/10.1097/CAD.0000000000001314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35946537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35946537"}]}]}]}
Synonyms MIR-4284
NCBI Gene ID 100422948
API
Download Associations
Predicted Functions View MIR4284's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4284's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4284's ARCHS4 Predicted Functions.

Functional Associations

MIR4284 has 264 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4284 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4284 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4284 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4284 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4284 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4284 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4284 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4284 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4284 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4284 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.