MIR4290 Gene

HGNC Family Non-coding RNAs
Name microRNA 4290
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in gastric cancer have underscored the importance of noncoding RNAs in tumorigenesis. In the work by PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", although the primary focus was on the oncogenic long noncoding RNA DLX6-AS1, the emerging landscape of noncoding RNA regulation in this malignancy prompts examination of additional molecules such as MIR4290. \n\nPreliminary insights suggest that MIR4290, a microRNA implicated in post‐transcriptional gene regulation, may participate in molecular networks that modulate oncogenic processes in gastric cancer. While the cited abstract does not detail the mechanistic role or targets of MIR4290 explicitly, its potential interplay with other noncoding RNAs like DLX6-AS1 hints at a collaborative contribution toward altering gene expression patterns that favor cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn summary, although the current abstract (PMID 32239379) primarily characterizes DLX6-AS1’s function in gastric cancer, the context it provides indirectly supports a model in which MIR4290 could serve as an additional regulatory factor within the complex noncoding RNA network driving oncogenic transformation. Further detailed studies will be indispensable to precisely delineate the role of MIR4290 in gastric cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Qian, Wei Song, Xu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DLX6 Antisense RNA 1 Modulates Glucose Metabolism and Cell Growth in Gastric Cancer by Targeting microRNA-4290."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-020-06223-4"}], "href": "https://doi.org/10.1007/s10620-020-06223-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32239379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32239379"}]}]}]}
NCBI Gene ID 100422963
API
Download Associations
Predicted Functions View MIR4290's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4290's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4290's ARCHS4 Predicted Functions.

Functional Associations

MIR4290 has 305 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR4290 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4290 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4290 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4290 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4290 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4290 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4290 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4290 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4290 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4290 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4290 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.