MIR4295 Gene

HGNC Family Non-coding RNAs
Name microRNA 4295
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐4295 (miR-4295) has emerged as an important regulatory molecule in cancer, acting in a context‐dependent manner to modulate tumorigenesis. In non‐small cell lung cancer, miR-4295 is reported to target the deubiquitinating enzyme USP28—a factor whose overexpression promotes cell proliferation and is associated with poor patient survival—suggesting that miR-4295 might influence USP28 levels and thereby affect tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In urothelial cells, the XIAP RING domain enhances Sp1-mediated transcription of miR-4295, which then binds to the 3’UTR of p63α mRNA to inhibit the expression of this tumor suppressor, a mechanism that contributes to malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic ductal adenocarcinoma, bioinformatic and experimental studies have identified Glypican-5 (GPC5)—a protein with tumor-suppressive properties—as a direct target of miR-4295, whereby miR-4295 action leads to enhanced cell proliferation, invasion, and activation of Wnt/β-catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In gliomas, elevated expression of miR-4295 correlates with advanced clinical stages; here, miR-4295 drives tumor progression by suppressing the tumor suppressor RUNX3, with N-myc contributing to this regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in head and neck squamous cell carcinoma, miR-4295 is upregulated and functions to promote cell proliferation, migration, and epithelial-to-mesenchymal transition by directly targeting NPTX1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn osteosarcoma, miR-4295 targets the tumor-suppressor phosphatase PTPN14, resulting in decreased phosphorylation and increased nuclear translocation of YAP1, an event that facilitates oncogenic transcription and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Furthermore, investigations in gastric cancer are focusing on elucidating the precise role and mechanisms of miR-4295 in disease pathogenesis, reinforcing its potential as a biomarker and therapeutic target across diverse tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Zhang, Biao Xu, Yong Qiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12426"}], "href": "https://doi.org/10.1111/jcmm.12426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25656529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25656529"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Honglei Jin, Jiheng Xu, Xirui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XIAP RING domain mediates miR-4295 expression and subsequently inhibiting p63α protein translation and promoting transformation of bladder epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10645"}], "href": "https://doi.org/10.18632/oncotarget.10645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27447744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27447744"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qinggong Yuan, Yan Zhang, Junhui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.02.023"}], "href": "https://doi.org/10.1016/j.bbrc.2018.02.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29407175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29407175"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xinxing Li, Jihui Zheng, Hongyu Diao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RUNX3 is down-regulated in glioma by Myc-regulated miR-4295."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.12736"}], "href": "https://doi.org/10.1111/jcmm.12736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26756701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26756701"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shun Lu, Cheng Zhou, Bingwen Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41435-019-0081-0"}], "href": "https://doi.org/10.1038/s41435-019-0081-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31118494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31118494"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gaofeng Liang, Chaopeng Duan, June He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTPN14, a target gene of miR-4295, restricts the growth and invasion of osteosarcoma cells through inactivation of YAP1 signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13296"}], "href": "https://doi.org/10.1111/1440-1681.13296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32141101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32141101"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaoyan Yang, Jing Yang, Yunlian Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4295 Promotes the Malignant Progression of Gastric Cancer "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Targeting PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207325666211110095307"}], "href": "https://doi.org/10.2174/1386207325666211110095307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34758714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34758714"}]}]}]}
NCBI Gene ID 100422909
API
Download Associations
Predicted Functions View MIR4295's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4295's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4295's ARCHS4 Predicted Functions.

Functional Associations

MIR4295 has 251 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4295 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4295 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4295 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4295 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4295 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4295 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4295 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR4295 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4295 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4295 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.