{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn studies of thyroid carcinoma, miR‐4299 has been identified as a critical regulator of tumor invasiveness. Its expression levels inversely correlate with the invasive phenotypes of follicular thyroid carcinoma cells, acting through the direct targeting of ST6GALNAC4—a member of the ST6GALNAC family—thereby modulating altered sialylation patterns that are closely associated with tumor progression. This molecular interaction suggests that miR‐4299 may serve both as a prognostic biomarker and as a potential therapeutic target in the modulation of tumorigenicity in thyroid cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn non‐small cell lung cancer, research has revealed that miR‐4299 expression is significantly correlated with clinicopathological features and patient prognosis. Alterations in its expression appear to influence cellular behaviors such as proliferation, migration, and invasion, possibly through the modulation of key components of the PTEN/AKT/PI3K signaling pathway. These findings point to a tumor suppressive role for miR‐4299 in NSCLC, where its downregulation may contribute to enhanced tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nIn pancreatic cancer, miR‐4299 is markedly downregulated compared to normal tissues, a change that contributes to tumor proliferation, invasion, and immune escape. Functional investigations have demonstrated that miR‐4299 exerts its suppressive effects via direct targeting of ADAM17; restoring ADAM17 expression can reverse these inhibitory effects. Consequently, the miR‐4299/ADAM17 axis emerges as an important regulatory mechanism, suggesting that miR‐4299 holds promise as both a biomarker and a therapeutic agent in pancreatic cancer management."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaolong Miao, Li Jia, Huimin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4299 mediates the invasive properties and tumorigenicity of human follicular thyroid carcinoma by targeting ST6GALNAC4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.1467"}], "href": "https://doi.org/10.1002/iub.1467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26715099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26715099"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "W-B Yang, W-P Zhang, J-L Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4299 suppresses non-small cell lung cancer cell proliferation, migration and invasion through modulating PTEN/AKT/PI3K pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201806_15163"}], "href": "https://doi.org/10.26355/eurrev_201806_15163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29917192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29917192"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junhong Liu, Lin Ye, Kangqiang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4299 inhibits tumor progression in pancreatic cancer through targeting ADAM17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-022-04617-8"}], "href": "https://doi.org/10.1007/s11010-022-04617-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36565360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36565360"}]}]}]}