MIR4300 Gene

HGNC Family Non-coding RNAs
Name microRNA 4300
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAdolescent idiopathic scoliosis (AIS) is a common spinal deformity in children, with curve progression being a major determinant of treatment and prognosis. A recent genome‐wide association study (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "identified a locus on chromosome 11q14.1 significantly associated with AIS curve progression. In this study, a functional variant, rs35333564, located in MIR4300HG—the host gene of microRNA MIR4300—was discovered. The genomic region encompassing this variant exhibits enhancer activity that is markedly reduced when the risk allele is present."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Diminished enhancer activity due to the risk allele results in decreased expression of MIR4300. This decrease is proposed to be directly related to the progression of the scoliotic curve in AIS patients, suggesting that MIR4300 plays a role in modulating the genetic mechanisms that underlie curve worsening."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Collectively, these data indicate that MIR4300, via its regulatory functions mediated by enhancer activity in MIR4300HG, may be an important molecular determinant in the progression of AIS. The study underscores the potential of MIR4300 as a biomarker for identifying AIS patients at higher risk of curve progression, which may aid in personalized management strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoji Ogura, Ikuyo Kou, Yohei Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional variant in MIR4300HG, the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx291"}], "href": "https://doi.org/10.1093/hmg/ddx291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29016859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29016859"}]}]}]}
NCBI Gene ID 100422823
API
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Predicted Functions View MIR4300's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4300's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4300's ARCHS4 Predicted Functions.

Functional Associations

MIR4300 has 199 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4300 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4300 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4300 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4300 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4300 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4300 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4300 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4300 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4300 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4300 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.