MIR4301 Gene

HGNC Family Non-coding RNAs
Name microRNA 4301
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, miR-4301 expression is significantly downregulated compared to normal tissues and cell lines, and its restoration suppresses cell proliferation while inducing apoptosis. These effects are mediated, at least in part, through negative regulation of Dopamine receptor D2 (DRD2), indicating that miR-4301 acts as a tumor suppressor by modulating DRD2 expression and consequently curbing cancer cell survival and growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, during rotavirus infection, miR-4301 expression is upregulated, and this enhancement plays a key role in promoting viral replication. Mechanistic investigations revealed that miR-4301 targets and downregulates the expression of PPP1R3D—a protein known to inhibit rotavirus replication—as well as glycogen synthase, thereby suppressing host glycogen synthesis and making more intracellular glucose available to support the virus’ replication process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naghmeh Gholipour, Anna Ohradanova-Repic, Ghasem Ahangari "}, {"type": "b", "children": [{"type": "t", "text": "A novel report of MiR-4301 induces cell apoptosis by negatively regulating DRD2 expression in human breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.26577"}], "href": "https://doi.org/10.1002/jcb.26577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29236292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29236292"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lijun Song, Xiaotong Wang, Peicheng Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host miR-4301 promotes rotavirus replication via PPP1R3D in Caco-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Virol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jmv.27208"}], "href": "https://doi.org/10.1002/jmv.27208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34260071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34260071"}]}]}]}
NCBI Gene ID 100422855
API
Download Associations
Predicted Functions View MIR4301's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4301's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4301's ARCHS4 Predicted Functions.

Functional Associations

MIR4301 has 255 functional associations with biological entities spanning 4 categories (molecular profile, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR4301 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4301 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4301 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4301 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4301 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4301 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4301 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4301 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR4301 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4301 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4301 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4301 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4301 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.