{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings in lung cancer have highlighted a novel regulatory axis in which the circular RNA hsa_circRNA_103809 promotes tumor progression by sequestering the microRNA miR‑4302, a molecule that under normal circumstances targets ZNF121. By sponging miR‑4302, hsa_circRNA_103809 prevents the microRNA from exerting its inhibitory effect on ZNF121, thereby facilitating increased ZNF121 expression and leading to the subsequent upregulation of MYC protein levels. This cascade ultimately enhances lung cancer cell proliferation and invasion, positioning the hsa_circRNA_103809/miR‑4302/ZNF121/MYC pathway as both a promising prognostic biomarker and a potential therapeutic target in lung cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Liu, Weiming Ma, Yuan Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.172"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29698681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29698681"}]}]}]}