{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRBBP7, a highly conserved chromatin remodeling factor also referred to as retinoblastoma‐binding protein 7, plays multifaceted roles in regulating cell fate and gene expression across diverse biological contexts. In the mammary gland, RBBP7 collaborates with noncoding RNAs like mPINC and polycomb repressive complex 2 components to maintain alveolar progenitor cells during pregnancy by inhibiting terminal differentiation, thereby ensuring that milk production is appropriately delayed until parturition (1). In mouse oocytes, RBBP7 is recruited during maturation to promote histone deacetylation—a process essential for the proper localization and operation of the chromosomal passenger complex, which in turn safeguards accurate chromosome segregation (2). Its expression in uterine stromal cells during the peri-implantation period also underscores a critical role in decidualization, where RBBP7 facilitates histone H4 acetylation and cyclin D3 expression in response to progesterone signaling (3). Early embryonic expression of RBBP7 in developing kidney and brain tissues further suggests its involvement in transcriptional repression of mitogen-responsive genes such as c-FOS (4). In neurodegenerative settings, such as Alzheimer’s disease, diminished levels of RBBP7 are linked with aberrant tau acetylation and hyperphosphorylation—findings that point to a neuroprotective function through modulation of p300 activity (5). Moreover, loss-of-function mutations in RBBP7 have been associated with male infertility, where disrupted germ cell progression leads to maturation arrest and increases the risk of testicular tumors due to compromised cell cycle regulation and heightened apoptosis (6). Finally, a circular RNA variant, circRBBP7, encodes a functional 13‐kDa protein that promotes myoblast proliferation and differentiation, potentially by modulating the VEGFR-1/MDM2/p53 signaling axis to facilitate muscle regeneration (7)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amy N Shore, Elena B Kabotyanski, Kevin Roarty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002840"}], "href": "https://doi.org/10.1371/journal.pgen.1002840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22911650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22911650"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ahmed Z Balboula, Paula Stein, Richard M Schultz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of RBBP7 unveils a requirement of histone deacetylation for CPC function in mouse oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.27410"}], "href": "https://doi.org/10.4161/cc.27410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24317350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24317350"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hui He, Shuangbo Kong, Fei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rbbp7 Is Required for Uterine Stromal Decidualization in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.115.129015"}], "href": "https://doi.org/10.1095/biolreprod.115.129015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26040671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26040671"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Yang, Susan Kiefer, Michael Rauchman "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the gene encoding mouse retinoblastoma binding protein-7, a component of chromatin-remodeling complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/geno.2002.6844"}], "href": "https://doi.org/10.1006/geno.2002.6844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12376095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12376095"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nikhil Dave, Austin S Vural, Ignazio S Piras, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-021-02323-1"}], "href": "https://doi.org/10.1007/s00401-021-02323-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33978814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33978814"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jingping Li, Huimei Zheng, Jiaru Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "X-linked RBBP7 mutation causes maturation arrest and testicular tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI171541"}], "href": "https://doi.org/10.1172/JCI171541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37843278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37843278"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yufeng Yang, Kongwei Huang, Hancai Jiang, et al. 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