{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR431 is emerging as a versatile regulator in non‐malignant contexts. In models of interferon response, adipogenic differentiation and autoimmune conditions such as Graves’ disease, MIR431 expression is modulated to influence fundamental cellular processes. For example, studies have shown that in intervertebral disc degeneration MIR431 targets inhibitors of Wnt signaling, while increased expression in preeclampsia placentas and necrotizing enterocolitis has been linked to inflammatory responses via down‐regulation of transcription factors such as FOXA1. Other investigations have demonstrated that MIR431 plays roles in pulmonary function by regulating surfactant homeostasis and in chondrocyte apoptosis associated with osteoarthritis, with additional evidence pointing toward its involvement in the regulation of inflammatory processes in rheumatoid arthritis and even in tailoring host responses relevant to novel RNA therapeutics for tuberculosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncologic arena MIR431 exhibits context‐dependent roles that modulate tumor proliferation, invasion and metastasis. In hepatocellular carcinoma, papillary thyroid carcinoma, pancreatic cancer, and melanoma, altered levels of MIR431 have been correlated with tumor progression and patient prognosis. In lung cancer, studies have revealed that long noncoding and circular RNAs function as molecular sponges for MIR431, thereby indirectly regulating targets such as RAF1 and influencing angiogenesis and cell migration. Similar mechanisms have been observed in tongue squamous cell carcinoma, esophageal carcinoma and neuroendocrine tumors, where MIR431 affects key pathways including Ras/extracellular signal–regulated kinase signaling and epithelial–mesenchymal transition. Moreover, in glioma, ovarian, nasopharyngeal, colon, and gastric cancers the MIR431-associated regulatory axis (which includes targets like NRXN3, PBOV1, SOX9, HCAR1, PRDX1, and SLC7A11) underscores its multifaceted action in tumor growth and apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the mechanistic level, MIR431 functions as a nodal regulator by interacting with various competing endogenous RNA networks across different tissue types. It directly binds to the 3′ untranslated regions of key modulators—such as SFRP1 and GSK‑3β in disc degeneration, FOXA1 in intestinal inflammation, DAB2IP in neuroendocrine tumor metastasis, and Smad4 in pulmonary surfactant regulation—to influence classical signaling cascades including Wnt, MAPK, and Ras/Erk. In addition, sponging interactions with circular and long noncoding RNAs have been shown to fine‑tune its availability and downstream effects on targets including NRXN3, SOX9, PBOV1, HCAR1, PRDX1, and SLC7A11. Collectively, these studies underscore the central role of MIR431 in coordinating diverse biological processes—ranging from inflammation and differentiation to tumor progression—thereby offering attractive prospects for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "22"}, {"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takeshi Tanaka, Shigeru Sugaya, Kazuko Kita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of cell viability by human IFN-β is mediated by microRNA-431."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2012.1345"}], "href": "https://doi.org/10.3892/ijo.2012.1345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22293894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22293894"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rongjiao Liu, Xinran Ma, Lingyan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-2982"}], "href": "https://doi.org/10.1210/jc.2011-2982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22456620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22456620"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yangling Wang, Lei Yang, Xiaofeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-431 inhibits adipogenic differentiation of human bone marrow-derived mesenchymal stem cells via targeting insulin receptor substance 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-018-0980-4"}], "href": "https://doi.org/10.1186/s13287-018-0980-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30165902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30165902"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaobin Wang, Bing Wang, Mingxiang Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircSEMA4B targets miR-431 modulating IL-1β-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2018.08.033"}], "href": "https://doi.org/10.1016/j.bbadis.2018.08.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30251693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30251693"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiuhua Yang, Tao Meng "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-431 affects trophoblast migration and invasion by targeting ZEB1 in preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.015"}], "href": "https://doi.org/10.1016/j.gene.2018.10.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30315928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30315928"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu Zheng Wu, Kathy Yuen Yee Chan, Kam Tong Leung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulation of miR-431 and target gene FOXA1 in intestinal tissues of infants with necrotizing enterocolitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201801470R"}], "href": "https://doi.org/10.1096/fj.201801470R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30624964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30624964"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shujun Li, Zhongyi Sun, Tao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of miR-431-5p in regulating pulmonary surfactant expression in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-019-0150-4"}], "href": "https://doi.org/10.1186/s11658-019-0150-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30988675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30988675"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qiwei Fu, Lexiang Li, Bo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircADAMTS6/miR-431-5p axis regulate interleukin-1β induced chondrocyte apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3304"}], "href": "https://doi.org/10.1002/jgm.3304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33305412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33305412"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bo Yu, Mengran Xiao, Fuhua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2021.105975"}], "href": "https://doi.org/10.1016/j.biocel.2021.105975"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33838342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33838342"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chenhui Yang, Qingling Liu, Zaiming Jiang "}, {"type": "b", "children": [{"type": "t", "text": "CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transpl Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trim.2022.101685"}], "href": "https://doi.org/10.1016/j.trim.2022.101685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35933079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35933079"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yung-Che Chen, Chang-Chun Hsiao, Chao-Chien Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Next generation sequencing reveals miR-431-3p/miR-1303 as immune-regulating microRNAs for active tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Infect (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jinf.2022.08.035"}], "href": "https://doi.org/10.1016/j.jinf.2022.08.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36057384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36057384"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "L Pan, F Ren, M Rong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between down-expression of miR-431 and clinicopathological significance in HCC tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-015-1278-y"}], "href": "https://doi.org/10.1007/s12094-015-1278-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25775917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25775917"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yang Liu, Lin Li, Zheng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of MiR-431 expression associated with lymph node metastasis and promotes cell invasion in papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-181253"}], "href": "https://doi.org/10.3233/CBM-181253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29945344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29945344"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J Yang, H Zhu, Y Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-431 inhibits cell proliferation and induces cell apoptosis by targeting CDK14 in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201807_15503"}], "href": "https://doi.org/10.26355/eurrev_201807_15503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30058687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30058687"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Qian Jiang, Li Cheng, Daiyuan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20181804"}], "href": "https://doi.org/10.1042/BSR20181804"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30610161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30610161"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "C-M Xu, L-X Chen, F Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-431 suppresses proliferation and metastasis of lung cancer via down-regulating DDX5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201901_16883"}], "href": "https://doi.org/10.26355/eurrev_201901_16883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30720177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30720177"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Grace T Y Kwok, Jing Ting Zhao, Anthony R Glover, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-431 as a Chemosensitizer and Potentiator of Drug Activity in Adrenocortical Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncologist (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/theoncologist.2018-0849"}], "href": "https://doi.org/10.1634/theoncologist.2018-0849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30918109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30918109"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Y-W Sun, X-H Li, H Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-431 is a prognostic marker and suppresses cell growth, migration and invasion by targeting NOTCH2 in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201905_17815"}], "href": "https://doi.org/10.26355/eurrev_201905_17815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31115015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31115015"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Y-T Hu, X-X Li, L-W Zeng "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201912_19668"}], "href": "https://doi.org/10.26355/eurrev_201912_19668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31841185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31841185"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Tiantian Zhang, Soyoung Choi, Tuo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2019.11.007"}], "href": "https://doi.org/10.1016/j.ajpath.2019.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31953039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31953039"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "KunZhe Wu, ChunDong Zhang, Cheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/5973082"}], "href": "https://doi.org/10.1155/2020/5973082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32104700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32104700"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Liang Liu, Peng Zhang, Xuchen Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03834-1"}], "href": "https://doi.org/10.1038/s41419-021-03834-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34035217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34035217"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Wei Zhu, Xiangming Xiao, Jinqin Chen "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the long noncoding RNA LINC01132 alleviates the oncogenicity of epithelial ovarian cancer by regulating the microRNA‑431‑5p/SOX9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4984"}], "href": "https://doi.org/10.3892/ijmm.2021.4984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34132375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34132375"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hongjun Dong, Chao Huang, Jingjing Huang "}, {"type": "b", "children": [{"type": "t", "text": "FBXL19‑AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR‑431 and upregulate PBOV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12286"}], "href": "https://doi.org/10.3892/mmr.2021.12286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34278444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34278444"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Hui Wang, Li Feng, Deyun Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA MAT2B promotes migration, invasion and epithelial-mesenchymal transition of non-small cell lung cancer cells by sponging miR-431."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1956106"}], "href": "https://doi.org/10.1080/15384101.2021.1956106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34288814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34288814"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Huajun Lu, Lili Gao, Jixiang Lv "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2021.100551"}], "href": "https://doi.org/10.1016/j.aohep.2021.100551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34606982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34606982"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jin Wang, Lei Zhou, Bingxin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-022-03240-x"}], "href": "https://doi.org/10.1186/s12967-022-03240-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35101080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35101080"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Øyvind P Haugen, Cuong Khuu, Hanne M Weidemann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2022.146346"}], "href": "https://doi.org/10.1016/j.gene.2022.146346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35182679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35182679"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Muwen Qu, Junyi Li, Zifu Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of human umbilical cord mesenchymal stem cells-derived exosomal microRNA-431-5p in survival and prognosis of colorectal cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutagenesis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/mutage/geac007"}], "href": "https://doi.org/10.1093/mutage/geac007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35460420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35460420"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yu Gao, Yichun Wang, Lei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hormones (Athens) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s42000-022-00378-7"}], "href": "https://doi.org/10.1007/s42000-022-00378-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35804263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35804263"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "J Wu, Z Deng, Y Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the Bax/Bcl-2/caspase3 pathway]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2023.04.05"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2023.04.05"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37202188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37202188"}]}]}]}