MIR4310 Gene

HGNC Family Non-coding RNAs
Name microRNA 4310
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research in colon cancer has revealed that the long noncoding RNA CASC15 is upregulated in tumor tissues and strongly correlates with advanced clinical stage and metastasis. Specifically, CASC15 functions as a molecular sponge for microRNA‐4310 (miR‐4310), thereby interfering with the microRNA’s ability to suppress its target gene, LGR5. Under normal conditions, miR‐4310 downregulates LGR5; however, when sequestered by CASC15, the elevated LGR5 levels activate the Wnt/β‐catenin signaling pathway, which in turn promotes colon cancer cell proliferation, migration, and invasion. This work implicates a miR‐4310/LGR5 axis in the mechanistic underpinning of tumor progression and suggests that manipulating this pathway may offer therapeutic benefits in colon cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMore broadly, microRNAs have emerged as valuable biomarkers in colorectal cancer research, reflecting the complexity of post‐transcriptional regulation in tumorigenesis. In this context, the functional insights regarding miR‐4310 highlight its potential not only as a regulatory molecule in oncogenic signaling but also as a candidate for future diagnostic and therapeutic strategies in colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Niancai Jing, Tao Huang, Huaiyu Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9191"}], "href": "https://doi.org/10.3892/mmr.2018.9191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29956772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29956772"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ziwei Jiang, Peiling Yi, Jinping You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differentially expressed miR-4310 functions as a tumor suppressor in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Health Care (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/THC-230472"}], "href": "https://doi.org/10.3233/THC-230472"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37545284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37545284"}]}]}]}
NCBI Gene ID 100423013
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Predicted Functions View MIR4310's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4310's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4310's ARCHS4 Predicted Functions.

Functional Associations

MIR4310 has 225 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR4310 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4310 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4310 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4310 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4310 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4310 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4310 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4310 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR4310 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4310 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4310 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.