{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence reveals that long non‐coding RNA LINC00472 plays a crucial anti‐tumor role in oral squamous cell carcinoma (OSCC) by functioning as a molecular sponge for hsa‐miR‑4311. By directly binding to miR‑4311, LINC00472 prevents this microRNA from repressing its target gene GNG7, a key regulator with tumor‐suppressive activity. Consequently, derepression of GNG7 leads to a reduction in OSCC progression and modulates the tumor immune response, as confirmed by both in vitro cellular studies and in vivo xenograft models where overexpression of LINC00472 significantly suppressed tumor growth. This competitive endogenous RNA network underscores the potential of targeting the LINC00472/miR‑4311/GNG7 axis as a novel therapeutic strategy in OSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Zou, Xiaozhi Lv, Haigang Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2040768"}], "href": "https://doi.org/10.1080/21655979.2022.2040768"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35240924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35240924"}]}]}]}