MIR4317 Gene

HGNC Family Non-coding RNAs
Name microRNA 4317
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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For instance, in non‐small cell lung cancer, microRNAs are being increasingly recognized for their utility in diagnosis and prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, research into the molecular mechanisms of RNA–protein complexes – such as the structural study of the yeast Paf1 complex – underlines the diverse functional capacities of RNA molecules, although that work does not directly address MIR4317."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA series of investigations have now uncovered that MIR4317 functions predominantly as a tumor suppressor in several solid tumors. In gastric cancer, MIR4317 expression is markedly decreased in tumor specimens relative to adjacent non‐tumor tissues, and its enforced expression suppresses cell proliferation and blocks the S-G2/M cell cycle transition through direct targeting of ZNF322."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, additional studies in gastric cancer patients suggest that MIR4317 may serve as a valuable prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn breast cancer, reduced expression of MIR4317 is associated with lymph node metastasis, advanced TNM stage, and poor prognosis. Functional experiments have demonstrated that overexpression of MIR4317 curbs cell proliferation, migration, and invasion, in part by directly suppressing MYD88."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma, MIR4317 levels are diminished in both patient tissues and cell lines, where its restoration impairs tumor cell viability, proliferation, invasion, and migration by targeting ZNF436 and modulating the PI3K/AKT pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xi He, Si-Yuan Chen, Zhao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4317 suppresses non-small cell lung cancer (NSCLC) by targeting fibroblast growth factor 9 (FGF9) and cyclin D2 (CCND2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0882-4"}], "href": "https://doi.org/10.1186/s13046-018-0882-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30227870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30227870"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rob N de Jong, Vincent Truffault, Tammo Diercks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and DNA binding of the human Rtf1 Plus3 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2007.10.018"}], "href": "https://doi.org/10.1016/j.str.2007.10.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18184592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18184592"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyi Hu, Min Zhang, Jiyu Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.10870"}], "href": "https://doi.org/10.1002/cbin.10870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28880489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28880489"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "J Zhang, Z-L Tian, W-T Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinicopathological and prognostic significance of miR-4317 expression in gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201904_17555"}], "href": "https://doi.org/10.26355/eurrev_201904_17555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31002131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31002131"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuwei Sheng, Rong Hu, Yi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-020-00625-4"}], "href": "https://doi.org/10.1007/s10238-020-00625-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32279128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32279128"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Li Zhang, Shuai Chang, Yao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4317 suppresses the progression of hepatocellular carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2021.101696"}], "href": "https://doi.org/10.1016/j.tice.2021.101696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34861581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34861581"}]}]}]}
NCBI Gene ID 100422840
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Download Associations
Predicted Functions View MIR4317's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4317's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4317's ARCHS4 Predicted Functions.

Functional Associations

MIR4317 has 286 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR4317 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4317 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4317 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4317 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4317 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4317 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR4317 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4317 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR4317 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4317 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4317 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.