MIR432 Gene

HGNC Family Non-coding RNAs
Name microRNA 432
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR‑432—including its mature forms miR‑432‑3p and miR‑432‑5p—plays a pivotal role in cancer biology by directly targeting several oncogenic regulators. For example, in melanoma cells, miR‑432 assists in silencing ADAR1, thereby modulating RNA editing and associated tumor phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, miR‑432‑3p targets KEAP1 to promote NRF2 stability and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Additionally, in hepatocellular carcinoma, forced miR‑432 expression suppresses Wnt/β‑catenin signaling by directly downregulating factors such as LRP6, TRIM29, and Pygo2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in lung adenocarcinoma, overexpression of miR‑432 induces cell‑cycle arrest and enhances sensitivity to cisplatin by targeting E2F3 and AXL."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, several noncoding RNAs have been shown to sequester miR‑432, thereby diminishing its tumor‐suppressive function and facilitating oncogenic signaling. In breast cancer and hepatocellular carcinoma, overexpressed circular RNAs such as circ_001569 act as competing endogenous RNAs (ceRNAs) by sponging miR‑432‑5p to elevate oncogenic targets like E2F3"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Similarly, in glioma and bladder cancer, long noncoding RNAs (e.g., ZFAS1 and DRAIC) or circRNAs (e.g., circ_100984) bind miR‑432—resulting in the derepression of their targets such as YBX‑1 and SLBP"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In cholangiocarcinoma, upregulation of circ‑ZNF609 sponges miR‑432‑5p to increase LRRC1 expression, further fueling tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Finally, heat shock factor 1 (HSF1) has been reported to regulate miR‑432 expression in response to proteotoxic stress"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", suggesting an additional layer of control linking stress responses to tumor biology. Together, these findings underscore miR‑432 as a critical tumor‑suppressive mediator whose downregulation or sequestration in various cancers contributes to increased proliferation, metastasis, and chemoresistance—highlighting its promise as a potential therapeutic target.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yael Nemlich, Eyal Greenberg, Rona Ortenberg, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3492"}], "href": "https://doi.org/10.18632/oncotarget.3492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25797263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25797263"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ling Chen, Guangming Kong, Chuantao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-432 functions as a tumor suppressor gene through targeting E2F3 and AXL in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7884"}], "href": "https://doi.org/10.18632/oncotarget.7884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942465"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yanhua Liu, Cuntao Lu, Yizhou Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.166"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29807010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29807010"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hongyuan Liu, Li Xue, Changyue Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.08.020"}], "href": "https://doi.org/10.1016/j.bbrc.2018.08.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30086881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30086881"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gongli Yang, Banghua Han, Tao Feng "}, {"type": "b", "children": [{"type": "t", "text": "ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up-regulating miR-432-5p in glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Clin Pharmacol Toxicol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bcpt.13286"}], "href": "https://doi.org/10.1111/bcpt.13286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31246330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31246330"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Liang Tong, Huihui Yang, Wei Xiong, et al. 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Synonyms MIR-432, MIRN432, HSA-MIR-432
NCBI Gene ID 574451
API
Download Associations
Predicted Functions View MIR432's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR432's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR432's ARCHS4 Predicted Functions.

Functional Associations

MIR432 has 332 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR432 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR432 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR432 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR432 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR432 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR432 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR432 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR432 from the GeneSigDB Published Gene Signatures dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR432 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR432 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR432 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.