{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA broad body of work has detailed the intricate mechanisms that govern amyloid precursor protein (APP) processing and the activity of its key protease BACE1 in Alzheimer’s disease. Numerous studies have explored every aspect of this cascade—from exosome‐mediated nucleic acid delivery and axonal APP transport to the proteolytic cleavage events that generate amyloid‑β peptides and affect synaptic function. These reports collectively demonstrate that precise enzymatic control and subcellular trafficking are critical for APP metabolism and that dysregulation of BACE1 activity, whether via post‐translational modifications or altered proteolytic processing, can drive neurodegenerative pathology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, several investigations have underscored the vital role of noncoding RNA species in regulating the amyloidogenic pathway. Multiple studies have highlighted that microRNAs such as miR‑29, miR‑195, miR‑298, and miR‑328—as well as antisense transcripts—can modulate BACE1 messenger RNA stability and translation, thereby influencing APP cleavage and amyloid‑β production. Despite this robust interest in RNA‐mediated control mechanisms, none of the provided abstracts offers any specific evidence regarding the function or targeting of MIR4322."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, the current literature emphasizes a complex, multilayered regulation of APP processing and BACE1 function in Alzheimer’s disease—with substantial attention given to microRNA‐ and antisense RNA–mediated post‐transcriptional controls. However, while these studies illuminate how various noncoding RNAs modulate amyloidogenic pathways, they do not elucidate any role for MIR4322. Thus, the specific function of MIR4322 remains undefined in these reports, and future research is warranted to determine whether MIR4322 might similarly influence BACE1 expression or other key steps in APP metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "28"}, {"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Kamal, A Almenar-Queralt, J F LeBlanc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/414643a"}], "href": "https://doi.org/10.1038/414643a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11740561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11740561"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maike Hartlage-Rübsamen, Ulrike Zeitschel, Jenny Apelt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.10178"}], "href": "https://doi.org/10.1002/glia.10178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509807"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yi Luo, Brad Bolon, Michael A Damore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0969-9961(03)00104-9"}], "href": "https://doi.org/10.1016/s0969-9961(03"}, {"type": "t", "text": "00104-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "13678669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/13678669"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Steve M Harrison, Alex J Harper, Julie Hawkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1044-7431(03)00227-6"}], "href": "https://doi.org/10.1016/s1044-7431(03"}, {"type": "t", "text": "00227-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14664815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14664815"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masuo Ohno, Evgeny A Sametsky, Linda H Younkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(03)00810-9"}], "href": "https://doi.org/10.1016/s0896-6273(03"}, {"type": "t", "text": "00810-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14715132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14715132"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hon-Kit Wong, Takashi Sakurai, Fumitaka Oyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M414648200"}], "href": "https://doi.org/10.1074/jbc.M414648200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15824102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15824102"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Diana Dominguez, Jos Tournoy, Dieter Hartmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505249200"}], "href": "https://doi.org/10.1074/jbc.M505249200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15987683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15987683"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fiona M Laird, Huaibin Cai, Alena V Savonenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2766-05.2005"}], "href": "https://doi.org/10.1523/JNEUROSCI.2766-05.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16354928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16354928"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michael Willem, Alistair N Garratt, Bozidar Novak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of peripheral nerve myelination by the beta-secretase BACE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1132341"}], "href": "https://doi.org/10.1126/science.1132341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16990514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16990514"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiangyou Hu, Caitlin W Hicks, Wanxia He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bace1 modulates myelination in the central and peripheral nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn1797"}], "href": "https://doi.org/10.1038/nn1797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17099708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17099708"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Masuo Ohno, Sarah L Cole, Marina Yasvoina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2006.12.008"}], "href": "https://doi.org/10.1016/j.nbd.2006.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17258906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17258906"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Doo Yeon Kim, Bryce W Carey, Haibin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 regulates voltage-gated sodium channels and neuronal activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1602"}], "href": "https://doi.org/10.1038/ncb1602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17576410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17576410"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lisa McConlogue, Manuel Buttini, John P Anderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611687200"}], "href": "https://doi.org/10.1074/jbc.M611687200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17616527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17616527"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Matthew A Wozniak, Ruth F Itzhaki, Suzanne J Shipley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2007.09.077"}], "href": "https://doi.org/10.1016/j.neulet.2007.09.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17980964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17980964"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "A V Savonenko, T Melnikova, F M Laird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0710373105"}], "href": "https://doi.org/10.1073/pnas.0710373105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18385378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18385378"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xiangyou Hu, Wanxia He, Claudiu Diaconu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-106666"}], "href": "https://doi.org/10.1096/fj.08-106666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18413858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18413858"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mohammad Ali Faghihi, Farzaneh Modarresi, Ahmad M Khalil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1784"}], "href": "https://doi.org/10.1038/nm1784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18587408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18587408"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mary Cabell Jonas, Claudio Costantini, Luigi Puglielli "}, {"type": "b", "children": [{"type": "t", "text": "PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2008.132"}], "href": "https://doi.org/10.1038/embor.2008.132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18660751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18660751"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Vincent Boissonneault, Isabelle Plante, Serge Rivest, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807530200"}], "href": "https://doi.org/10.1074/jbc.M807530200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18986979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18986979"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sarah E Hoey, Robert J Williams, Michael S Perkinton "}, {"type": "b", "children": [{"type": "t", "text": "Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6017-08.2009"}], "href": "https://doi.org/10.1523/JNEUROSCI.6017-08.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19357271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19357271"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiangyou Hu, Xiangdong Zhou, Wanxia He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BACE1 deficiency causes altered neuronal activity and neurodegeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1334-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.1334-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20592204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20592204"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lydia Alvarez-Erviti, Yiqi Seow, Haifang Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Biotechnol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nbt.1807"}], "href": "https://doi.org/10.1038/nbt.1807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21423189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21423189"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Lujia Zhou, Soraia Barão, Mathias Laga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.377465"}], "href": "https://doi.org/10.1074/jbc.M112.377465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22692213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22692213"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hong-Can Zhu, Li-Mei Wang, Miao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res Bull (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainresbull.2012.05.018"}], "href": "https://doi.org/10.1016/j.brainresbull.2012.05.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22721728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22721728"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Peer-Hendrik Kuhn, Katarzyna Koroniak, Sebastian Hogl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2012.173"}], "href": "https://doi.org/10.1038/emboj.2012.173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22728825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22728825"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Raja Bhattacharyya, Cory Barren, Dora M Kovacs "}, {"type": "b", "children": [{"type": "t", "text": "Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4704-12.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.4704-12.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23825420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23825420"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201404438"}], "href": "https://doi.org/10.15252/emmm.201404438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25592972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25592972"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Gahee Bahn, Jong-Sung Park, Ui Jeong Yun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1819541116"}], "href": "https://doi.org/10.1073/pnas.1819541116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31164420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31164420"}]}]}]}