{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the intricate regulation of cell fate by various coding and non‐coding RNAs. One investigation focused on the role of BRI3 in TNF-induced cell death, revealing that interference with bri3 expression using antisense RNA confers extraordinary resistance to TNF-mediated apoptosis, potentially via lysosome-associated mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nMeanwhile, miR-4326 has been identified as an important oncogenic microRNA in lung cancer. Analysis of patient tissues and lung cancer cell lines demonstrated that miR-4326 is significantly upregulated, and its overexpression promotes cell proliferation, colony formation, and DNA synthesis. Mechanistically, miR-4326 directly targets the tumor suppressor gene APC2—an inhibitor of the Wnt pathway—thereby relieving its repression and leading to increased expression of Wnt-driven proliferative mediators such as Cyclin D1 and c-MYC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nCollectively, these findings illustrate how distinct molecular entities can shape cell survival and proliferation: while BRI3 influences apoptotic responses to inflammatory stimuli, miR-4326 functions as an oncogenic regulator by subverting tumor suppressive pathways. This emerging complexity in RNA-mediated regulation highlights potential targets for therapeutic intervention in diseases ranging from inflammatory cell death to cancer.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haoquan Wu, Gang Liu, Changben Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.10.038"}], "href": "https://doi.org/10.1016/j.bbrc.2003.10.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14592447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14592447"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guopeng Xu, Zhongwei Zhang, Li Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4326 promotes lung cancer cell proliferation through targeting tumor suppressor APC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3219-2"}], "href": "https://doi.org/10.1007/s11010-017-3219-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29101731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29101731"}]}]}]}