{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research on sporadic colorectal cancer has identified miR-4328 as a potential regulator of epidermal growth factor receptor (EGFR) expression specifically in metastatic tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In these studies, miR-4328 was found to interact with EGFR in metastatic cases, suggesting that it may contribute to the upregulation of EGFR that is associated with lymph node and liver metastases as well as with advanced tumor stages and adverse clinical outcomes. This post‐transcriptional regulatory role contrasts with that of miR-134—which appears to affect EGFR in non-metastatic tumors—highlighting a context-dependent function of microRNAs in colorectal cancer.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation examining innate immune mechanisms through the study of the LysMD3 protein"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", no direct involvement or functional attribution of miR-4328 was reported. This absence underlines that the regulatory function of miR-4328 may be largely tissue‐ or context-specific, with significant implications in colorectal cancer metastasis rather than in the general regulation of innate immune components.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sofía Del Carmen, Luís Antonio Corchete, Ruth Gervas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-61688-7"}], "href": "https://doi.org/10.1038/s41598-020-61688-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32170146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32170146"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christine C Yokoyama, Megan T Baldridge, Daisy W Leung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LysMD3 is a type II membrane protein without an "}, {"type": "a", "children": [{"type": "t", "text": "b"}], "href": "b"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vivo"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "a", "children": [{"type": "t", "text": "/b"}], "href": "/b"}, {"type": "t", "text": " role in the response to a range of pathogens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.001246"}], "href": "https://doi.org/10.1074/jbc.RA117.001246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29496999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29496999"}]}]}]}