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"}, {"type": "b", "children": [{"type": "t", "text": "miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroimmunomodulation (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000518084"}], "href": "https://doi.org/10.1159/000518084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34518486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34518486"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ying Guo, Weilin Xue, Shuli Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0179860"}], "href": "https://doi.org/10.1371/journal.pone.0179860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28628652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28628652"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "X Lin, K L Rice, M Buzzai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2012.224"}], "href": "https://doi.org/10.1038/leu.2012.224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22864358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22864358"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Guisheng Song, Li Wang "}, {"type": "b", "children": [{"type": "t", "text": "A conserved gene structure and expression regulation of miR-433 and miR-127 in mammals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007829"}], "href": "https://doi.org/10.1371/journal.pone.0007829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19946636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19946636"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Lorena de Mena, Lucía F Cardo, Eliecer Coto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2010.05.019"}], "href": "https://doi.org/10.1016/j.neulet.2010.05.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20471450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20471450"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Neha S Dole, Kristina Kapinas, Catherine B Kessler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2378"}], "href": "https://doi.org/10.1002/jbmr.2378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25262637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25262637"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Rui Wang, Jingjing Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of miR-433 in the diagnosis of Alzheimer's disease and its effect on Aβ-induced neurotoxicity by regulating JAK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Gerontol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exger.2020.111080"}], "href": "https://doi.org/10.1016/j.exger.2020.111080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32871216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32871216"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Kejing Wang, Li Li, Junjun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The different expression profiles of microRNAs in elderly and young human dental pulp and the role of miR-433 in human dental pulp cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Ageing Dev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mad.2015.03.001"}], "href": "https://doi.org/10.1016/j.mad.2015.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25778413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25778413"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Lin Zhang, Yuanxiao Zhang, Xiaohua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-016-0853-1"}], "href": "https://doi.org/10.1007/s12031-016-0853-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27815672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27815672"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xinmei Liu, Shasha Huang, Yun Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA OSER1‑AS1 promotes the malignant properties of non‑small cell lung cancer by sponging microRNA‑433‑3p and thereby increasing Smad2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7645"}], "href": "https://doi.org/10.3892/or.2020.7645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32627026"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32627026"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "C-L Zhou, F Li, X-W Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miRNA-433-5p protects acute spinal cord injury through activating MAPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20644"}], "href": "https://doi.org/10.26355/eurrev_202003_20644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32271400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32271400"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Naruchorn Kijpaisalratana, Pattaraporn Nimsamer, Ariya Khamwut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miRNA125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to differentiate between posterior circulation stroke and peripheral vertigo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-020-01946-3"}], "href": "https://doi.org/10.1186/s12883-020-01946-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33038923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33038923"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Hua Cheng, Wei Yan "}, {"type": "b", "children": [{"type": "t", "text": "MiR-433 Regulates Myocardial Ischemia Reperfusion Injury by Targeting NDRG4 Via the PI3K/Akt Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Shock (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/SHK.0000000000001532"}], "href": "https://doi.org/10.1097/SHK.0000000000001532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32187107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32187107"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Mehri Naghdalipour, Nariman Moradi, Reza Fadaei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of miR-21, miR-433 and miR-590 tissue expression related to the TGF-β signaling pathway in ulcerative colitis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Physiol Biochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13813455.2020.1762656"}], "href": "https://doi.org/10.1080/13813455.2020.1762656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32412349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32412349"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Karen M Jiménez, Angela J Pereira-Morales, Ana Adan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Brain (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13041-018-0397-0"}], "href": "https://doi.org/10.1186/s13041-018-0397-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30241547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30241547"}]}]}]}