{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPreeclampsia is a complex, pregnancy‐related disorder with significant implications for both maternal and fetal health. Recent investigations have focused on the involvement of microRNAs in the pathogenesis of this condition. In one such study, the regulatory role of miR-4421 was examined, revealing that alterations in the expression of this miRNA may influence key cellular processes—such as trophoblast invasion, endothelial function, and inflammatory signaling—that are critical for proper placental development and function. The findings suggest that dysregulation of miR-4421 could contribute to the development of preeclampsia by perturbing underlying gene regulatory networks, thereby offering a potential target for future therapeutic intervention and a novel biomarker for disease onset."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X Gao, H Li, J-X Wei "}, {"type": "b", "children": [{"type": "t", "text": "MiR-4421 regulates the progression of preeclampsia by regulating CYP11B2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201803_14557"}], "href": "https://doi.org/10.26355/eurrev_201803_14557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29630094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29630094"}]}]}]}