{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn patients with advanced breast cancer, brain metastasis represents a critical clinical challenge associated with a poor prognosis. Recent evidence indicates that serum miR-4428 can serve as a novel biomarker for brain metastasis, as its expression levels significantly differentiate patients with brain involvement from those without. In this study, miR-4428 demonstrated a promising diagnostic performance, with an area under the receiver operating characteristic curve (AUC) of 0.779, and when combined with the progesterone receptor status, the accuracy further increased (AUC of 0.884)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Tincidunt vel sagittis quam convallis varius phasellus tincidunt. Libero ultrices libero fermentum lectus ex nunc felis. Turpis felis lectus feugiat sapien sagittis. Interdum diam tempor quisque lacinia lobortis libero. Posuere ex nam mi libero gravida aliquet donec."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. While miR-4428 appears specific to the metastatic progression in breast cancer, other non-coding RNAs, such as lncRNA ACTA2-AS1, are under investigation for their roles in metastasis in other malignancies, including papillary thyroid carcinoma. These collective findings underscore the growing importance of circulating RNA markers in cancer diagnostics and the potential for future studies to validate miR-4428 as part of non‐invasive diagnostic strategies for early detection of brain metastases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Sato, Akihiko Shimomura, Junpei Kawauchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain metastasis-related microRNAs in patients with advanced breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0221538"}], "href": "https://doi.org/10.1371/journal.pone.0221538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31603918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31603918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuhui Wu, Jingjing Zhu, Tingting Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-023-01622-6"}], "href": "https://doi.org/10.1186/s13148-023-01622-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38195623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38195623"}]}]}]}