{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐4429 (miR‐4429) has emerged as a critical tumor‐suppressive regulator in several cancers via directly targeting key oncogenic mediators. In gastric cancer, for instance, miR‐4429 targets METTL3 to inhibit m⁶A‐mediated stabilization of SEC62 and thereby suppress proliferation while promoting apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cervical cancer, miR‐4429 enhances radiosensitivity by binding to RAD51 and impairing DNA repair, thus reducing radio‐resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in papillary thyroid carcinoma, downregulation of miR‐4429—resulting from sponging by the oncogenic lncRNA LINC00313—leads to tumor progression that can be reversed upon restoration of miR‐4429 levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In clear cell renal cell carcinoma, miR‐4429 functions to inhibit tumor cell proliferation, migration, invasion, and epithelial–mesenchymal transition by directly targeting CDK6."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In glioblastoma, an oncogenic feedback loop is established whereby the lncRNA DLEU1 sequesters miR‐4429 to result in SP1 overexpression, while re‐establishing miR‐4429 levels attenuates these deleterious effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these contexts, miR‐4429 is implicated in modulating tumor progression in a range of other malignancies. In ovarian cancer, its altered expression has been linked to changes in cell migratory potential"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in prostate cancer miR‐4429 regulates oncogenic pathways to restrain disease advancement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, the circular RNA circABCA13 functions as a molecular sponge for miR‐4429, which leads to increased SRXN1 expression and promotes malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In non‐small cell lung cancer, miR‐4429 directly binds to EGFR, with lower miR‐4429 levels correlating with increased EGFR expression and poorer prognosis; this observation is further underscored by studies involving the LINC00313/miR‐4429 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In colon cancer, miR‐4429‐5p suppresses tumor cell proliferation, migration, and invasion by directly targeting MMP16."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In renal cell carcinoma, overexpression of the lncRNA FTX sponges miR‐4429 to release UBE2C from inhibition, thereby promoting cell cycle progression and tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Moreover, in gastric cancer, exosomal circKIAA1797 sequesters miR‐4429 to modulate PBX3 expression, leading to enhanced malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, miR‐4429 is also of interest beyond oncology; dysregulated levels in the blood of schizophrenia patients highlight its potential as a novel biomarker for early diagnosis and prognosis in neuropsychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huabo He, Wei Wu, Zhener Sun, et al. 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