{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn esophageal cancer research involving KHSRP knockdown, hsa‐miR‐4430 (MIR4430) was identified as a key microRNA embedded in a complex regulatory network of noncoding and coding RNAs. The study revealed that lncRNA RP11-159D12.2 may serve as a competing endogenous RNA (ceRNA) by binding to hsa‐miR‐4430, thereby modulating the expression of BIRC5—a gene enriched in mitotic nuclear division and found upregulated in tumor tissues. This ceRNA interaction suggests that MIR4430 facilitates the derepression of BIRC5, contributing to abnormal cell cycle regulation and tumor progression in esophageal cancer. Moreover, the observation that both BIRC5 and PLK1 (a hub gene in relevant protein–protein interaction modules) were upregulated and positively correlated with KHSRP further highlights the coordinated role of MIR4430 in this oncogenic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ling Chen, Tiejun Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2020.3745"}], "href": "https://doi.org/10.1089/cbr.2020.3745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32673063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32673063"}]}]}]}