{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐4437 functions as a negative post‐transcriptional regulator of CXCR2, a key receptor that mediates the chemotactic effects of CXCL8. In ischemic stroke, decreased levels of miR‐4437 in peripheral leukocytes lead to enhanced CXCR2 expression, which in turn correlates with increased recruitment of inflammatory granulocytes and natural killer cells. This dysregulated chemotactic axis contributes to larger infarct volumes and poorer functional outcomes, suggesting that miR‐4437 could serve as a promising therapeutic target to modulate post‐stroke inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlthough many of the provided abstracts primarily explore the diverse biological roles and regulation of acidic mammalian chitinase (AMCase) in airway inflammation, fibrosis, digestive processes, and protein engineering, the report on miR‐4437 distinctly highlights its involvement in immune cell recruitment during ischemic brain injury. This finding underscores the importance of post‐transcriptional regulation in inflammatory diseases and opens potential avenues for targeting miR‐4437 to rebalance the CXCL8–CXCR2 chemotactic axis in ischemic stroke."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qianyi He, Xiaojuan Shi, Bin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2018.08.002"}], "href": "https://doi.org/10.1016/j.molimm.2018.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30096583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30096583"}]}]}]}