MIR4442 Gene

HGNC Family Non-coding RNAs
Name microRNA 4442
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR4442 has emerged as an important microRNA in colorectal cancer (CRC), serving both as a potential biomarker for early recurrence and as a functional mediator of cancer progression. Elevated levels of circulating MIR4442 in the plasma of CRC patients correlate with early disease relapse, and its increased expression is especially notable in metastatic liver lesions compared to normal liver and colorectal tissues. Functional studies indicate that overexpression of MIR4442 enhances the proliferative, migratory, and invasive properties of CRC cells. Mechanistically, MIR4442 directly targets the mRNA of RBMS1, a putative tumor suppressor, leading to its downregulation. This reduction in RBMS1 is accompanied by alterations in epithelial-mesenchymal transition (EMT) markers, namely, decreased levels of the epithelial marker E-cadherin and increased expression of mesenchymal markers such as N-cadherin and the transcription factor Snail1. These findings not only reinforce the clinical utility of MIR4442 as a prognostic biomarker for predicting early recurrence in CRC but also highlight its active role in promoting EMT-related tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Shibamoto, Tomohiro Arita, Hirotaka Konishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of miR-4442 in Colorectal Cancer: Predicting Early Recurrence and Regulating Epithelial-Mesenchymal Transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes14071414"}], "href": "https://doi.org/10.3390/genes14071414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37510319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37510319"}]}]}]}
Synonyms MIR-4442
NCBI Gene ID 100616477
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Predicted Functions View MIR4442's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4442's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4442's ARCHS4 Predicted Functions.

Functional Associations

MIR4442 has 1,171 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR4442 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4442 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4442 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4442 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4442 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4442 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4442 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR4442 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4442 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4442 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.