MIR4443 Gene

HGNC Family Non-coding RNAs
Name microRNA 4443
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have uncovered the multifaceted roles of miR‐4443 in the regulation of cancer cell behavior and chemoresistance. In breast cancer, miR‐4443 was first identified as a novel regulator associated with chemoresistance and malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioblastoma, overexpression of miR‐4443 inhibited cell proliferation, migration, and invasion through a reciprocal interaction with the long noncoding RNA MNX1‐AS1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while in non–small cell lung cancer, increased miR‐4443 levels promoted resistance to chemotherapeutics by targeting INPP4A and activating the JAK2/STAT3 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, silencing of miR‐4443 by the oncogenic lncRNA FEZF1‐AS1 is associated with enhanced tumor growth and metastasis; restoration of miR‐4443 impedes these malignant processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In a contrasting scenario in breast cancer, exosomal miR‐4443 was shown to facilitate metastasis by downregulating tissue inhibitors of metalloproteinases (TIMP2) and consequently upregulating matrix metalloproteinases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Complementing these findings, mechanistic studies have revealed that miR‐4443 is produced via a non‐canonical biogenesis pathway independent of Drosha, Exportin-5, and Dicer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther investigations have delineated additional context-dependent roles for miR‐4443. In head and neck squamous cell carcinoma, the long noncoding RNA LINC00460 promotes cell progression by sponging miR‐4443, thereby facilitating proliferation and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In papillary thyroid carcinoma, miR‐4443 targets TRIM14 to suppress metastasis and reduce aerobic glycolysis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Its ability to drive cell migration and invasion has also been underscored in additional breast cancer studies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, comprehensive analyses indicate that miR‐4443 modulates multiple downstream pathways affecting cell proliferation, invasion, and drug resistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", a concept further strengthened by evidence in BRAF‐mutant melanoma linking its upregulation to acquired resistance to targeted therapies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Collectively, these findings underscore the context‐dependent dual functionality of miR‐4443 in oncogenesis—acting either as a tumor suppressor or as an oncomiR—and highlight its promising potential as both a biomarker and therapeutic target in various malignancies.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiu Chen, Shan-Liang Zhong, Peng Lu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "lncRNA MNX1-AS1 Promotes Glioblastoma Progression Through Inhibition of miR-4443."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15228909735079"}], "href": "https://doi.org/10.3727/096504018X15228909735079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678219"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weiguo Zhang, Bin Qiao, Junli Fan "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmazie (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1691/ph.2018.8313"}], "href": "https://doi.org/10.1691/ph.2018.8313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30001772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30001772"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jianhua Gong, Junyi Wang, Tianpin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA FEZF1‑AS1 contributes to cell proliferation, migration and invasion by sponging miR‑4443 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9585"}], "href": "https://doi.org/10.3892/mmr.2018.9585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30365146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30365146"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jinyan Wang, Qian Zhang, Dandan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29507"}], "href": "https://doi.org/10.1002/jcp.29507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31970775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31970775"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ari Meerson "}, {"type": "b", "children": [{"type": "t", "text": "Leptin-Responsive MiR-4443 Is a Small Regulatory RNA Independent of the Canonic MicroRNA Biogenesis Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom10020293"}], "href": "https://doi.org/10.3390/biom10020293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32069948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32069948"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Meng Li, Xiaomin Zhang, Xu Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00460 Promotes Cell Progression by Sponging miR-4443 in Head and Neck Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Transplant (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0963689720927405"}], "href": "https://doi.org/10.1177/0963689720927405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32478564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32478564"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiao-Ming Zuo, Hai-Wen Sun, Hong Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11631"}], "href": "https://doi.org/10.1002/cbin.11631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34051007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34051007"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jinyan Wang, Jinqiu Wang, Quan Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[MiR-4443 promotes migration and invasion of breast cancer cells by inhibiting PEBP1 expression]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2020.12.03"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2020.12.03"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33380387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33380387"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yunan Mao, Jinze Shen, Yuchen Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant expression of microRNA-4443 (miR-4443) in human diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2109807"}], "href": "https://doi.org/10.1080/21655979.2022.2109807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36250718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36250718"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Vittorio Castaldo, Michele Minopoli, Francesca Di Modugno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-023-02878-9"}], "href": "https://doi.org/10.1186/s13046-023-02878-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38008717"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38008717"}]}]}]}
Synonyms MIR-4443
NCBI Gene ID 100616407
API
Download Associations
Predicted Functions View MIR4443's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4443's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4443's ARCHS4 Predicted Functions.

Functional Associations

MIR4443 has 535 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR4443 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4443 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4443 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4443 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4443 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4443 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4443 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4443 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4443 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4443 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4443 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.