{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn a study of hypopharyngeal squamous cell carcinoma (HSCC), MIR4451 was identified as one of the upregulated microRNAs among a panel of nine candidates screened for prognostic relevance. The investigation, which enrolled a total of 511 HSCC patients undergoing surgery followed by post‐operative radiotherapy, revealed that high MIR4451 expression—when combined with elevated levels of miR‑200a‑3p and miR‑30b‑5p—correlates significantly with poorer overall survival and disease‐specific survival. This finding suggests that MIR4451 plays a role in the aggressive behavior of HSCC, serving as a valuable component of a microRNA signature that can independently predict increased risks of mortality."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In essence, the upregulation of MIR4451 is indicative of an unfavorable prognosis, and its integration into a prognostic biomarker panel could help stratify patients for personalized therapeutic approaches. Its association with approximately a twofold increased risk of both overall death and HSCC‐related death underscores the potential utility of MIR4451 as a clinical marker for identifying high‐risk patients who may benefit from more aggressive or tailored management strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinbo Xu, Zhongming Lu, Neil Gross, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 3-miRNA signature predicts survival of patients with hypopharyngeal squamous cell carcinoma after post-operative radiotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14702"}], "href": "https://doi.org/10.1111/jcmm.14702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31578816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31578816"}]}]}]}