MIR4456 Gene

HGNC Family Non-coding RNAs
Name microRNA 4456
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThis study investigated hypersexual disorder (HD) by examining epigenetic modifications in miRNA‐associated CpG‐sites, focusing on the role of MIR4456. A specific CpG‐site (cg01299774) associated with MIR4456 showed borderline differential methylation between individuals with HD and healthy volunteers, and importantly, lower expression levels of MIR4456 were observed in subjects with HD. These findings suggest that altered methylation at cg01299774 may contribute to the dysregulation of MIR4456 in HD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nFurther analysis revealed that methylation levels at this CpG site are inversely correlated with the expression of MIR4456, reinforcing the idea that epigenetic regulation plays a significant role in its expression. Notably, similar methylation alterations were also identified in alcohol dependence, which hints at overlapping mechanisms between HD and substance-related disorders, potentially via modifications that affect MIR4456 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, gene target prediction and pathway analysis indicated that MIR4456 likely targets genes that are predominantly expressed in the brain and involved in major neuronal signaling pathways, including the oxytocin signaling pathway. This connection to oxytocin signaling suggests that MIR4456 may influence critical neuronal mechanisms underlying impulse control and sexual desire regulation, thereby contributing to the pathophysiology of HD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adrian E Boström, Andreas Chatzittofis, Diana-Maria Ciuculete, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2019.1656157"}], "href": "https://doi.org/10.1080/15592294.2019.1656157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31542994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31542994"}]}]}]}
NCBI Gene ID 100616381
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Predicted Functions View MIR4456's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4456's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4456's ARCHS4 Predicted Functions.

Functional Associations

MIR4456 has 267 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR4456 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4456 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4456 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4456 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4456 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4456 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4456 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4456 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4456 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.