{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non-coding RNAs (lncRNAs) are emerging as crucial regulators in cancer biology, and recent research highlights the role of MIR4458HG in human hepatocellular carcinoma (HCC). This lncRNA was found to be differentially expressed in HCC tissues compared to paired normal liver samples, and its manipulation using siRNAs or overexpression vectors significantly altered cell proliferation and colony formation. These initial findings underscore its potential influence on glucose metabolism and cancer cell physiology"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n\nMechanistic studies revealed that MIR4458HG exerts its oncogenic effects by directly binding to IGF2BP2, a pivotal m6A RNA-binding protein. This interaction enhances the stability of key mRNAs such as HK2 and SLC2A1 (GLUT1), which are central players in the glycolytic pathway. Consequently, the activation of glycolysis by MIR4458HG supports the altered metabolic demands of tumor cells in HCC"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n\nIn addition to its direct impact on tumor cells, MIR4458HG was observed to be encapsulated within exosomes secreted by HCC cells. These exosomal particles facilitate the polarization of tumor-associated macrophages toward a phenotype marked by increased ARG1 expression, thereby potentially contributing to an immunosuppressive microenvironment that favors tumor progression. Given these multifaceted functions in both cancer cell metabolism and the tumor microenvironment, MIR4458HG represents a promising therapeutic target for HCC patients with high glucose metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Ye, Menghan Wang, Guoyu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-023-04741-8"}], "href": "https://doi.org/10.1007/s00018-023-04741-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36933158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36933158"}]}]}]}