{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies provided here does not report any direct findings on MIR4468. Instead, these works focus on defining the molecular mechanisms that underlie excitatory synapse assembly, receptor trafficking, and synaptic plasticity through the actions of postsynaptic scaffold proteins such as SAP102, PSD-95, and other members of the Dlg-MAGUK family. For example, one study revealed that an exocyst–SAP102–NMDAR complex is critical for trafficking NMDA receptors to the cell surface, underscoring the importance of precise receptor delivery for neuronal communication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations dissected the roles of these scaffolding proteins during synapse development and maturation, highlighting a developmental hand‐off from SAP102 to PSD-95 in regulating the synaptic incorporation of glutamate receptors and the consequent changes in synaptic strength. In turn, these processes are essential for cognitive functions and are implicated in neurodevelopmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": " Additionally, complementary studies outlined how other members of these protein families contribute to synaptic organization and plasticity across different brain regions and developmental stages."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while none of these abstracts directly address or characterize MIR4468, they collectively outline a highly orchestrated framework of synaptic regulation mediated by scaffold proteins that control receptor localization, synapse formation, and plasticity, all of which are critical for learning, memory, and overall brain function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": " Given the well‐defined roles of these proteins, future research may explore whether microRNAs like MIR4468 could exert regulatory control over the expression of key postsynaptic components, thereby indirectly influencing synaptic dynamics and associated cognitive processes."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nathalie Sans, Kate Prybylowski, Ronald S Petralia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb990"}], "href": "https://doi.org/10.1038/ncb990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12738960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12738960"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peter C Cuthbert, Lianne E Stanford, Marcelo P Coba, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs large tumor suppressor binds preferentially to SAP102."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.101"}], "href": "https://doi.org/10.1002/iub.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18618587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18618587"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "G M Elias, L A B Elias, P F Apostolides, et al. 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