MIR4469 Gene

HGNC Family Non-coding RNAs
Name microRNA 4469
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into esophageal squamous cell carcinoma (ESCC) have elucidated a novel oncogenic pathway in which MIR4469 plays a critical regulatory role. In particular, circRNA_141539 is significantly up-regulated in ESCC and acts as a sponge for MIR4469, thereby diminishing its normal inhibitory effect on cyclin-dependent kinase-3 (CDK3). Under appropriate conditions, MIR4469 appears to function as a tumor-suppressive microRNA by negatively regulating CDK3 expression. However, when sequestered by circRNA_141539, the suppression of CDK3 is relieved, ultimately promoting cell proliferation and invasion and correlating with more advanced tumor stage and poorer patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these findings, emerging research into non-coding RNAs in cancer has begun to characterize other regulatory networks, such as those involving long non-coding RNAs (lncRNAs) like HLA complex group 11 (HCG11) in laryngeal carcinoma. Although MIR4469 is not directly implicated in these studies, the broader investigation of non-coding RNA interactions underscores the complexity of post-transcriptional regulation in tumorigenesis and the potential for crosstalk among various classes of regulatory RNAs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zheng-Hua Liu, Shi-Ze Yang, Wen-Ya Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103071"}], "href": "https://doi.org/10.18632/aging.103071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33504681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33504681"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H-X Xue, H-F Li, T Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202003_20684"}], "href": "https://doi.org/10.26355/eurrev_202003_20684"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32271435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32271435"}]}]}]}
Synonyms MIR-4469
NCBI Gene ID 100616115
API
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Predicted Functions View MIR4469's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR4469's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR4469's ARCHS4 Predicted Functions.

Functional Associations

MIR4469 has 1,212 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 13 datasets.

Click the + buttons to view associations for MIR4469 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4469 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4469 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR4469 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4469 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4469 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR4469 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR4469 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR4469 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR4469 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR4469 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR4469 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR4469 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR4469 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.