{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn conditions of oxidative stress, microRNA‐4470 plays a critical regulatory role by interacting with the 3′‐UTR of SUCNR1 mRNA. Specifically, the presence of a single nucleotide polymorphism (rs13079080) in SUCNR1 creates a binding site for miRNA‐4470, which, when the C allele is present, leads to a 60% decrease in SUCNR1 expression as demonstrated by luciferase reporter assays. In contrast, the T allele disrupts miRNA‐4470 binding, potentially resulting in higher SUCNR1 expression and an enhanced ability to sense and respond to oxidative stress. This modulation of SUCNR1 expression may contribute to the observed protective effect of the T allele against age‐related macular degeneration, suggesting that miRNA‐4470 is an important post‐transcriptional regulator in oxidative stress–associated diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elja M M Louer, Laura Lorés-Motta, Ana Mãdãlina Ion, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2019.1643100"}], "href": "https://doi.org/10.1080/15476286.2019.1643100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31304868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31304868"}]}]}]}