{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, miR‐4484 has been identified as an intragenic microRNA located on chromosome 10 that is frequently deleted and downregulated. Functional investigations demonstrated that restoring miR‐4484 in glioma cells suppresses colony formation and reduces migratory capabilities, indicating its tumor‐suppressive role likely mediated through the regulation of key oncogenic targets involved in gliomagenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, in systemic sclerosis the circulating levels of miR‐4484 are markedly elevated. Bioinformatics analyses suggest that miR‐4484 could regulate critical components of the fibrotic process, including elements of the transforming growth factor‐β signaling pathway, extracellular matrix receptor interactions, and metalloproteinase expression—most notably implicating a potential link with MMP-21—thereby proposing a novel biomarker role in the disease’s pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, research in gastric cancer reveals that miR‐4484 is significantly downregulated in tumor tissues compared with adjacent normal mucosa. The reduced expression of this miRNA shows an inverse correlation with the upregulation of ITGA6, a direct target of miR‐4484, suggesting that loss of miR‐4484 may contribute to enhanced invasion and metastasis in gastric cancer. These findings highlight miR‐4484 as a potential prognostic marker and therapeutic target in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zahid Nawaz, Vikas Patil, Sivaarumugam Thinagararjan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of somatic copy number alterations on the glioblastoma miRNome: miR-4484 is a genomically deleted tumour suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12060"}], "href": "https://doi.org/10.1002/1878-0261.12060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28378523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28378523"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marta Rusek, Małgorzata Michalska-Jakubus, Małgorzata Kowal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-50695-y"}], "href": "https://doi.org/10.1038/s41598-019-50695-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31582779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31582779"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "H Y Zhong, Y Zhong, Y Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[MiR-4484 regulates the expression of integrin α 6 in gastric cancer tissues and its significance]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112152-20200404-00305"}], "href": "https://doi.org/10.3760/cma.j.cn112152-20200404-00305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35316874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35316874"}]}]}]}