{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have identified microRNA-4487 (miR-4487) as a novel regulator of autophagy. In a study focused on Parkinson’s disease models, in silico prediction and microarray analyses revealed that miR-4487 directly targets ULK1, a key kinase responsible for initiating the autophagic process. Experimental validation indicated that by binding to ULK1, miR-4487 modulates ULK1-mediated autophagy, suggesting that this miRNA may serve as a critical negative regulator within this pathway. This finding highlights an emerging role for miR-4487 in the neuroprotective response to cellular stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a complementary line of research, the dysregulation of miR-4487 has also been implicated in vascular pathophysiology. Specifically, altered levels of miR-4487 are under investigation for their impact on the proliferation, migration, and apoptosis of vascular smooth muscle cells—key processes involved in atherosclerosis development. Although the precise molecular mechanisms remain to be fully elucidated, these studies suggest that miR-4487 might have potential as a biomarker or therapeutic target in cardiovascular diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi Chen, Shuya Wang, Lan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep11035"}], "href": "https://doi.org/10.1038/srep11035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26183158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26183158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao Liang, Miaoyang Hu, Wei Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4487 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting RAS p21 protein activator 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.153903"}], "href": "https://doi.org/10.1016/j.prp.2022.153903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35483305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35483305"}]}]}]}